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• W64825105 abstract "Research for new biocompatible and easily implantable materials continuouslyproposes new molecules and new substances with biological, chemical and physicalcharacteristics, that are more and more adapted to aesthetic and reconstructivesurgery and to the development of biomedical devices such as cardiovascularprostheses.Two classes of polymeric biomaterials seem to meet better these requirements:“hydrogels” , which includes polyalkylimide (PAI) and polyvinylalcohol (PVA) and“elastomers”, which includes polyurethanes (PUs). The first ones in the last decadehave had a great application for soft tissue augmentation, due to their similarity tothis tissue for their high water content, elasticity and oxygen permeability (Dini etal., 2005). The second ones, on the contrary, are widely used in cardiovascularapplications (catheters, vascular grafts, ventricular assist devices, total artificialhearts) due to their good mechanical properties and hemocompatibility (ZdrahalaR.J. and Zdrahala I.J., 1999).In the biocompatibility evaluation of these synthetic polymers, that is important forits potential use in clinical applications, a fundamental aspect is the knowledge of thepolymers cytotoxicity and the effect of their interaction with cells, in particular withthe cell populations involved in the inflammatory responses, i.e.monocyte/macrophages.In consideration of what above said, the aim of this study is the comprehension ofthe in vitro effect of PAI, PVA and PU on three cell lines that represent threedifferent stages of macrophagic differentiation: U937 pro-monocytes, THP-1monocytes and RAW 264.7 macrophages.Cytotoxicity was evaluated by measuring the rate of viability with MTT, Neutral Redand morphological analysis at light microscope in time-course dependentexperiments.The influence of these polymers on monocyte/macrophage activation in terms ofcells adhesion, monocyte differentiation in macrophages, antigens distribution,aspecific phagocytosis, fluid-phase endocitosis, pro-inflammatory cytokine (TNF-α,IL-1β, IL-6) and nitric oxide (NO) release was evaluated.In conclusion, our studies have indicated that the three different polymericbiomaterials are highly biocompatible, since they scarcely affected viability of U937,THP-1 and RAW 264.7 cells. Moreover, we have found that even though hydrogelsand polyurethane influences monocyte/macrophage differentiation (depending on theparticular type of cell and polymer), they are immunocompatible since they notinduced significantly high cytokine release. For these reasons their clinicalapplications are strongly encouraged." @default.
• W64825105 created "2016-06-24" @default.
• W64825105 creator A5047002579 @default.
• W64825105 date "2008-05-23" @default.
• W64825105 modified "2023-09-27" @default.
• W64825105 title "Differenziamento macrofagico: gli effetti dei polimeri sintetici" @default.
• W64825105 doi "https://doi.org/10.6092/unibo/amsdottorato/698" @default.
• W64825105 hasPublicationYear "2008" @default.
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