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- W64884074 abstract "Alcohol abuse is known to induce immunosuppression involving the depletion of CD4+ T cells; however the mechanisms underlying this alcohol effect are not clearly understood. Recent work from our laboratory showed that ethanol decreases S-adenosylmethionine (SAM) levels and enhances activation-induced apoptotic cell death (AICD) in CD4+ T cells. SAM is a critical methyl donor and impacts epigenetic variations involving histone modifications which play a key role in altering chromatin structure and transcriptional activity. Accordingly, the present work was carried out to investigate the immunotoxic effects of ethanol by examining FasL promoter histone modifications in the regulation of FasL gene expression in CD4+ T lymphocytes exposed to alcohol. Examination of the FasL promoter in CD4+ T cells exposed to ethanol showed increased histone H3 acetylation which is associated with active transcription. In correspondence with increased histone acetylation ethanol was observed to recruit the histone acetyltransferase and transcriptional co-activator p300. Notably, the histone modifications induced by ethanol enhanced NFAT transcription factor binding and correlated with increased FasL expression. These data strongly support the notion that epigenetic modifications involving histones are critical in ethanol-induced FasL expression and AICD in CD4+ T cells and ensuing immunosuppression." @default.
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- W64884074 date "2010-04-01" @default.
- W64884074 modified "2023-10-16" @default.
- W64884074 title "Epigenetic Modifications Of Histones Play A Critical Role In Ethanol‐Mediated Enhancement Of FasL Gene Expression And Cell Death In CD4 + T Lymphocytes" @default.
- W64884074 doi "https://doi.org/10.1096/fasebj.24.1_supplement.759.6" @default.
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