Matches in SemOpenAlex for { <https://semopenalex.org/work/W64912384> ?p ?o ?g. }
- W64912384 endingPage "336" @default.
- W64912384 startingPage "297" @default.
- W64912384 abstract "The nuclear factor κB (NF-κB) family is an evolutionarily conserved family of transcription factors that play a central role in immune and inflammatory responses. They also play a pivotal role in cell survival, whereby activation of NF-κB antagonizes programmed cell death induced by tumor necrosis factor receptors and other cell death signals. The prosurvival function of NF-κB has been implicated in a wide range of biological processes, including the development and homeostasis of the immune system and liver. It has also been implicated in the pathogenesis of numerous diseases, including cancer, chronic inflammation, and certain hereditary disorders. The protective activity of NF-κB can also hamper tumor cell killing inflicted by radiation or chemotherapeutic drugs, thereby promoting resistance to cancer treatments. This prosurvival activity of NF-κB involves the suppression of sustained c-Jun N-terminal kinase (JNK) activation and of the accumulation of cytotoxic reactive oxygen species. NF-κB mediates this function by inducing the transcription of target genes, whose products inhibit the JNK signaling pathway and suppress accumulation of reactive oxygen species through their antioxidant functions. The development of specific inhibitors that target the critical downstream NF-κB-regulated genes that promote survival in cancer and other diseases potentially holds a key to developing specific and effective therapeutic strategies to combat these disorders." @default.
- W64912384 created "2016-06-24" @default.
- W64912384 creator A5017597678 @default.
- W64912384 creator A5020878566 @default.
- W64912384 creator A5046488140 @default.
- W64912384 creator A5082145701 @default.
- W64912384 creator A5083283790 @default.
- W64912384 date "2013-01-01" @default.
- W64912384 modified "2023-09-27" @default.
- W64912384 title "The Regulation of the JNK Cascade and Programmed Cell Death by NF-κB: Mechanisms and Functions" @default.
- W64912384 cites W1501881225 @default.
- W64912384 cites W1523845694 @default.
- W64912384 cites W1530165617 @default.
- W64912384 cites W1530284699 @default.
- W64912384 cites W1533021978 @default.
- W64912384 cites W1563090311 @default.
- W64912384 cites W158576505 @default.
- W64912384 cites W1588586944 @default.
- W64912384 cites W1596801838 @default.
- W64912384 cites W1598875012 @default.
- W64912384 cites W1649938880 @default.
- W64912384 cites W1778624427 @default.
- W64912384 cites W1822745879 @default.
- W64912384 cites W1880841984 @default.
- W64912384 cites W1919878195 @default.
- W64912384 cites W1935708014 @default.
- W64912384 cites W1962878424 @default.
- W64912384 cites W1963510913 @default.
- W64912384 cites W1964780858 @default.
- W64912384 cites W1964951140 @default.
- W64912384 cites W1965037168 @default.
- W64912384 cites W1965913972 @default.
- W64912384 cites W1966923590 @default.
- W64912384 cites W1968985125 @default.
- W64912384 cites W1969296748 @default.
- W64912384 cites W1970338050 @default.
- W64912384 cites W1971240021 @default.
- W64912384 cites W1972128179 @default.
- W64912384 cites W1973562447 @default.
- W64912384 cites W1973839771 @default.
- W64912384 cites W1973862406 @default.
- W64912384 cites W1974679488 @default.
- W64912384 cites W1976590012 @default.
- W64912384 cites W1979032223 @default.
- W64912384 cites W1980447537 @default.
- W64912384 cites W1982062664 @default.
- W64912384 cites W1983195932 @default.
- W64912384 cites W1983536745 @default.
- W64912384 cites W1983761290 @default.
- W64912384 cites W1985914508 @default.
- W64912384 cites W1986060421 @default.
- W64912384 cites W1987827289 @default.
- W64912384 cites W1987989553 @default.
- W64912384 cites W1988230895 @default.
- W64912384 cites W1988463809 @default.
- W64912384 cites W1988587254 @default.
- W64912384 cites W1990752073 @default.
- W64912384 cites W1992841021 @default.
- W64912384 cites W1993936200 @default.
- W64912384 cites W1995335649 @default.
- W64912384 cites W1995747121 @default.
- W64912384 cites W1998642504 @default.
- W64912384 cites W2000054651 @default.
- W64912384 cites W2001790179 @default.
- W64912384 cites W2003043352 @default.
- W64912384 cites W2005572311 @default.
- W64912384 cites W2007456673 @default.
- W64912384 cites W2007515325 @default.
- W64912384 cites W2007868505 @default.
- W64912384 cites W2008181517 @default.
- W64912384 cites W2008693250 @default.
- W64912384 cites W2009128649 @default.
- W64912384 cites W2011698659 @default.
- W64912384 cites W2015089689 @default.
- W64912384 cites W2015604710 @default.
- W64912384 cites W2018460745 @default.
- W64912384 cites W2020045401 @default.
- W64912384 cites W2020987391 @default.
- W64912384 cites W2022900996 @default.
- W64912384 cites W2025166772 @default.
- W64912384 cites W2025366035 @default.
- W64912384 cites W2026679068 @default.
- W64912384 cites W2026814494 @default.
- W64912384 cites W2028432878 @default.
- W64912384 cites W2028882640 @default.
- W64912384 cites W2031721732 @default.
- W64912384 cites W2031855605 @default.
- W64912384 cites W2033479150 @default.
- W64912384 cites W2033528838 @default.
- W64912384 cites W2033586457 @default.
- W64912384 cites W2033810895 @default.
- W64912384 cites W2033882650 @default.
- W64912384 cites W2034236127 @default.
- W64912384 cites W2035135710 @default.
- W64912384 cites W2037106665 @default.
- W64912384 cites W2039421163 @default.
- W64912384 cites W2039478887 @default.
- W64912384 cites W2044696727 @default.