Matches in SemOpenAlex for { <https://semopenalex.org/work/W64946871> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W64946871 abstract "Currently probabilistic models of protein families, namely HMMs, are the methodology of choice for remote homology analysis. Unfortunately, the topology of such so-called Profile HMMs is rather complex which, despite sophisticated regularization techniques, is problematic for robust model estimation when only little training data is available.We propose a new HMM based protein family modeling method using building blocks which capture the essentials of particular targets only. They are estimated in a fully data-driven and unsupervised procedure. Contrary to current motif detection procedures we use a feature based protein sequence representation we developed earlier. Such small building blocks are automatically combined to global protein family HMMs which can be applied to remote homology analysis tasks.The results of an experimental evaluation on a challenging task of remote homology classification prove that robust models containing substantially smaller amounts of parameters can be estimated using the new modeling approach. The smaller the number of parameters to be trained, the smaller the number of training samples required which is of major importance for e.g. drug discovery tasks." @default.
- W64946871 created "2016-06-24" @default.
- W64946871 creator A5000532612 @default.
- W64946871 creator A5048407937 @default.
- W64946871 date "2005-01-01" @default.
- W64946871 modified "2023-09-27" @default.
- W64946871 title "A New Approach for HMM based Protein Sequence Modeling and its Application to Remote Homology Classification" @default.
- W64946871 cites W1550791608 @default.
- W64946871 cites W2009570821 @default.
- W64946871 cites W2085277871 @default.
- W64946871 cites W2097555181 @default.
- W64946871 cites W2099946731 @default.
- W64946871 cites W2102122585 @default.
- W64946871 cites W2152350018 @default.
- W64946871 hasPublicationYear "2005" @default.
- W64946871 type Work @default.
- W64946871 sameAs 64946871 @default.
- W64946871 citedByCount "1" @default.
- W64946871 crossrefType "journal-article" @default.
- W64946871 hasAuthorship W64946871A5000532612 @default.
- W64946871 hasAuthorship W64946871A5048407937 @default.
- W64946871 hasConcept C104317684 @default.
- W64946871 hasConcept C11413529 @default.
- W64946871 hasConcept C119857082 @default.
- W64946871 hasConcept C124101348 @default.
- W64946871 hasConcept C153180895 @default.
- W64946871 hasConcept C154945302 @default.
- W64946871 hasConcept C165525559 @default.
- W64946871 hasConcept C23224414 @default.
- W64946871 hasConcept C2776135515 @default.
- W64946871 hasConcept C2874115 @default.
- W64946871 hasConcept C41008148 @default.
- W64946871 hasConcept C49937458 @default.
- W64946871 hasConcept C54355233 @default.
- W64946871 hasConcept C86803240 @default.
- W64946871 hasConceptScore W64946871C104317684 @default.
- W64946871 hasConceptScore W64946871C11413529 @default.
- W64946871 hasConceptScore W64946871C119857082 @default.
- W64946871 hasConceptScore W64946871C124101348 @default.
- W64946871 hasConceptScore W64946871C153180895 @default.
- W64946871 hasConceptScore W64946871C154945302 @default.
- W64946871 hasConceptScore W64946871C165525559 @default.
- W64946871 hasConceptScore W64946871C23224414 @default.
- W64946871 hasConceptScore W64946871C2776135515 @default.
- W64946871 hasConceptScore W64946871C2874115 @default.
- W64946871 hasConceptScore W64946871C41008148 @default.
- W64946871 hasConceptScore W64946871C49937458 @default.
- W64946871 hasConceptScore W64946871C54355233 @default.
- W64946871 hasConceptScore W64946871C86803240 @default.
- W64946871 hasLocation W649468711 @default.
- W64946871 hasOpenAccess W64946871 @default.
- W64946871 hasPrimaryLocation W649468711 @default.
- W64946871 hasRelatedWork W118790501 @default.
- W64946871 hasRelatedWork W1496233740 @default.
- W64946871 hasRelatedWork W1663078778 @default.
- W64946871 hasRelatedWork W1893081301 @default.
- W64946871 hasRelatedWork W1894180423 @default.
- W64946871 hasRelatedWork W2009432620 @default.
- W64946871 hasRelatedWork W2085140422 @default.
- W64946871 hasRelatedWork W2086765355 @default.
- W64946871 hasRelatedWork W2104983234 @default.
- W64946871 hasRelatedWork W2112815320 @default.
- W64946871 hasRelatedWork W2139706309 @default.
- W64946871 hasRelatedWork W2149134893 @default.
- W64946871 hasRelatedWork W2170960297 @default.
- W64946871 hasRelatedWork W2184875454 @default.
- W64946871 hasRelatedWork W2222511249 @default.
- W64946871 hasRelatedWork W2309400895 @default.
- W64946871 hasRelatedWork W2886334658 @default.
- W64946871 hasRelatedWork W80262151 @default.
- W64946871 hasRelatedWork W156039636 @default.
- W64946871 hasRelatedWork W93014965 @default.
- W64946871 isParatext "false" @default.
- W64946871 isRetracted "false" @default.
- W64946871 magId "64946871" @default.
- W64946871 workType "article" @default.