Matches in SemOpenAlex for { <https://semopenalex.org/work/W64948013> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W64948013 abstract "Publisher Summary This chapter describes the activation of isolated T cells in chronic lymphocytic leukemia (CLL) by mitogens. Twenty-four patients and 20 healthy blood donors were studied in an experiment described in the chapter. Lymphocyte subpopulations were obtained either by passage over nylon wool columns or by separating E-rosette forming cells (E-RFC) from nonrosetting cells by density gradient centrifugation. Mitogen-induced lymphocyte activation as measured by 3H-thymidine incorporation was tested in microcultures. Approximately 60% of normal lymphocytes were retained on the columns; only about 5% of chronic lymphocytic leukemia (CLL) lymphocytes passed through the nylon columns. Nylon-wool-filtered normal lymphocytes consisted of about 72% E-RFC and less than 1% Ig-positive cells or monocytes. In CLL, the mean percentage of E-RFC increased from 5 to 36%, and the percentage of Ig-positive cells was less than 2%. Unfractionated CLL lymphocytes showed a markedly impaired response to PHA, ConA and PWM. Nylon-wool-filtered CLL lymphocytes gave 4–5-fold higher thymidine incorporation in response to PHA; the response to ConA, however, was completely abolished in almost all experiments. In some cases, the PWM-induced response was also substantially lower." @default.
- W64948013 created "2016-06-24" @default.
- W64948013 creator A5021523215 @default.
- W64948013 creator A5036587184 @default.
- W64948013 creator A5043975461 @default.
- W64948013 creator A5079224022 @default.
- W64948013 creator A5088369784 @default.
- W64948013 date "1977-01-01" @default.
- W64948013 modified "2023-10-16" @default.
- W64948013 title "ACTIVATION OF ISOLATED T CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) BY MITOGENS" @default.
- W64948013 cites W1965572371 @default.
- W64948013 cites W1999516176 @default.
- W64948013 cites W2069316372 @default.
- W64948013 cites W2071565229 @default.
- W64948013 doi "https://doi.org/10.1016/b978-0-12-458050-3.50127-2" @default.
- W64948013 hasPublicationYear "1977" @default.
- W64948013 type Work @default.
- W64948013 sameAs 64948013 @default.
- W64948013 citedByCount "0" @default.
- W64948013 crossrefType "book-chapter" @default.
- W64948013 hasAuthorship W64948013A5021523215 @default.
- W64948013 hasAuthorship W64948013A5036587184 @default.
- W64948013 hasAuthorship W64948013A5043975461 @default.
- W64948013 hasAuthorship W64948013A5079224022 @default.
- W64948013 hasAuthorship W64948013A5088369784 @default.
- W64948013 hasConcept C153911025 @default.
- W64948013 hasConcept C185592680 @default.
- W64948013 hasConcept C19869320 @default.
- W64948013 hasConcept C202751555 @default.
- W64948013 hasConcept C203014093 @default.
- W64948013 hasConcept C2777108182 @default.
- W64948013 hasConcept C2777761686 @default.
- W64948013 hasConcept C2777938653 @default.
- W64948013 hasConcept C2778461978 @default.
- W64948013 hasConcept C552990157 @default.
- W64948013 hasConcept C55493867 @default.
- W64948013 hasConcept C7623868 @default.
- W64948013 hasConcept C86803240 @default.
- W64948013 hasConceptScore W64948013C153911025 @default.
- W64948013 hasConceptScore W64948013C185592680 @default.
- W64948013 hasConceptScore W64948013C19869320 @default.
- W64948013 hasConceptScore W64948013C202751555 @default.
- W64948013 hasConceptScore W64948013C203014093 @default.
- W64948013 hasConceptScore W64948013C2777108182 @default.
- W64948013 hasConceptScore W64948013C2777761686 @default.
- W64948013 hasConceptScore W64948013C2777938653 @default.
- W64948013 hasConceptScore W64948013C2778461978 @default.
- W64948013 hasConceptScore W64948013C552990157 @default.
- W64948013 hasConceptScore W64948013C55493867 @default.
- W64948013 hasConceptScore W64948013C7623868 @default.
- W64948013 hasConceptScore W64948013C86803240 @default.
- W64948013 hasLocation W649480131 @default.
- W64948013 hasOpenAccess W64948013 @default.
- W64948013 hasPrimaryLocation W649480131 @default.
- W64948013 hasRelatedWork W112644937 @default.
- W64948013 hasRelatedWork W1494323907 @default.
- W64948013 hasRelatedWork W1546234834 @default.
- W64948013 hasRelatedWork W1589405436 @default.
- W64948013 hasRelatedWork W1979861671 @default.
- W64948013 hasRelatedWork W2081386087 @default.
- W64948013 hasRelatedWork W2084358065 @default.
- W64948013 hasRelatedWork W2087206511 @default.
- W64948013 hasRelatedWork W2133996533 @default.
- W64948013 hasRelatedWork W2338688120 @default.
- W64948013 hasRelatedWork W2398203085 @default.
- W64948013 hasRelatedWork W2414018870 @default.
- W64948013 hasRelatedWork W2414568152 @default.
- W64948013 hasRelatedWork W2416633839 @default.
- W64948013 hasRelatedWork W2460361720 @default.
- W64948013 hasRelatedWork W2536980390 @default.
- W64948013 hasRelatedWork W2583269404 @default.
- W64948013 hasRelatedWork W334754881 @default.
- W64948013 hasRelatedWork W338180378 @default.
- W64948013 hasRelatedWork W71638399 @default.
- W64948013 isParatext "false" @default.
- W64948013 isRetracted "false" @default.
- W64948013 magId "64948013" @default.
- W64948013 workType "book-chapter" @default.