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- W64962480 endingPage "324" @default.
- W64962480 startingPage "273" @default.
- W64962480 abstract "The Notch gene was first identified in Drosophila as a locus required for development of many structures (Poulson 1937). The diversity of biological processes regulated by Notch in Drosophila and its varied relatives from C. elegans to man is only now becoming clear. Indeed the Notch receptor system may be used to regulate development and homeostasis of every tissue in complex animals. Some of these processes have been analyzed in great detail and we refer readers to several excellent recent reviews focused on more biological aspects of Notch function (Artavanis-Tsakonas et al. 1995; Kopan and Turner 1996; Lardelli et al. 1995). Genetic analysis of invertebrate Notch family receptors has highlighted a role of Notch proteins as transmembrane transcription factors which require proteolytic activation and nuclear translocation for activity. Numerous proteins which participate in the Notch signaling pathway have been discovered. These varied proteins include ligands for Notch, regulators of Notch ligand-binding specificity, regulators of Notch signaling efficiency, and transcription factors which cooperate with Notch to control gene expression. In this article we will highlight the structural features of Notch receptors and the proteins with which they interact. These structures are conserved in all Notch-family receptors and their partners. Through the analysis of structure and function together, we hope to highlight some important features of these signaling proteins which may help to explain their role in integrating many extracellular signals to control cell fate determination, differentiation, proliferation and cell survival." @default.
- W64962480 created "2016-06-24" @default.
- W64962480 creator A5015608281 @default.
- W64962480 creator A5041043128 @default.
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- W64962480 date "1998-01-01" @default.
- W64962480 modified "2023-10-18" @default.
- W64962480 title "Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions" @default.
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