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- W64974854 abstract "Abstract Splenic marginal zones (MZ) are architecturally organized to generate a rapid response against blood borne antigens entering the spleen. Proper alignment includes MZ B cells, MARCO+ MZ macrophages (MZM), and MOMA1+ metallophilic macrophages positioned around a MAdCAM-1+ cell lined sinus. Our objective was to assess cell specific morphological changes of the MZ in young vs aged mice. We observed gross changes in the spleens of aged mice that reflect the improper alignment of cells in the MZ. Immunocytochemistry and immunofluorescence were used to reveal the positioning of MAdCAM-1+ sinus lining cells and MZM or MOMA1+ macrophages. As reported, in young mice, a continuous single cell layer of MAdCAM-1+ cells enveloped the white pulp, in addition to a cohesive line of MZM and MOMA1+ macrophages closely aligned with MAdCAM-1+ cells. In contrast, the MAdCAM-1+ cells of aged mice were more diffuse and less organized. MOMA1+ macrophages were also discontinuous and highly diffused into the white pulp and B-cell follicles. MAdCAM-1+ cells were surrounded by discontinuous, patchy groups of MZM. The reduction of MZM in aged spleens was confirmed by evaluating the ability of MZM to bind the FITC-labeled Dextran in vivo. By flow cytometry, the reduction in MZM in individual aged mice statistically correlated with reduced frequency of MZB cells. These changes may affect the ability of the MZ to properly respond to and clear pathogens in aged mice. NIH RO1AG013874 and T32AG031780" @default.
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- W64974854 date "2010-04-01" @default.
- W64974854 modified "2023-09-25" @default.
- W64974854 title "Altered cellular organization of the splenic marginal zone in aged mice (132.24)" @default.
- W64974854 doi "https://doi.org/10.4049/jimmunol.184.supp.132.24" @default.
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