Matches in SemOpenAlex for { <https://semopenalex.org/work/W64987177> ?p ?o ?g. }
- W64987177 endingPage "40" @default.
- W64987177 startingPage "233" @default.
- W64987177 abstract "Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are cytokines produced primarily by monocytes and macrophages with regulatory effects in inflammation and multiple aspects of the immune response. As yet, no molecular data have been reported for IL-1beta and TNF-alpha of the beluga whale. In this study, we cloned and determined the entire cDNA sequence encoding beluga whale IL-1beta and TNF-alpha. The genetic relationship of the cytokine sequences was then analyzed with those from several mammalian species, including the human and the pig. The homology of beluga whale IL-1beta nucleic acid and deduced amino acid sequences with those from these mammalian species ranged from 74.6 to 86.0% and 62.7 to 77.1%, respectively, whereas that of TNF-alpha varied from 79.3 to 90.8% and 75.3 to 87.7%, respectively. Phylogenetic analyses based on deduced amino acid sequences showed that the beluga whale IL-1beta and TNF-alpha were most closely related to those of the ruminant species (cattle, sheep, and deer). The beluga whale IL-1beta- and TNF-alpha-encoding sequences were thereafter successfully expressed in Escherichia coli as fusion proteins by using procaryotic expression vectors. The fusion proteins were used to produce beluga whale IL-1beta- and TNF-alpha-specific rabbit antisera." @default.
- W64987177 created "2016-06-24" @default.
- W64987177 creator A5007689245 @default.
- W64987177 creator A5015340719 @default.
- W64987177 date "2001-10-01" @default.
- W64987177 modified "2023-10-16" @default.
- W64987177 title "Molecular cloning and characterization of beluga whale (Delphinapterus leucas) interleukin-1beta and tumor necrosis factor-alpha." @default.
- W64987177 cites W1517287118 @default.
- W64987177 cites W1574330564 @default.
- W64987177 cites W1915347135 @default.
- W64987177 cites W1915518296 @default.
- W64987177 cites W1923254440 @default.
- W64987177 cites W1971514924 @default.
- W64987177 cites W1973127065 @default.
- W64987177 cites W1981163610 @default.
- W64987177 cites W1983977756 @default.
- W64987177 cites W1989783048 @default.
- W64987177 cites W1994704939 @default.
- W64987177 cites W2009310436 @default.
- W64987177 cites W2027689158 @default.
- W64987177 cites W2034157754 @default.
- W64987177 cites W2039354633 @default.
- W64987177 cites W2039428188 @default.
- W64987177 cites W2075274039 @default.
- W64987177 cites W2080532845 @default.
- W64987177 cites W2081179798 @default.
- W64987177 cites W2085486418 @default.
- W64987177 cites W2086183741 @default.
- W64987177 cites W2087050793 @default.
- W64987177 cites W2112979433 @default.
- W64987177 cites W2138270253 @default.
- W64987177 cites W2161571451 @default.
- W64987177 cites W2165129178 @default.
- W64987177 cites W2165453428 @default.
- W64987177 cites W2232791900 @default.
- W64987177 cites W2408607935 @default.
- W64987177 cites W69813697 @default.
- W64987177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1189685" @default.
- W64987177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11768130" @default.
- W64987177 hasPublicationYear "2001" @default.
- W64987177 type Work @default.
- W64987177 sameAs 64987177 @default.
- W64987177 citedByCount "6" @default.
- W64987177 countsByYear W649871772014 @default.
- W64987177 countsByYear W649871772016 @default.
- W64987177 countsByYear W649871772018 @default.
- W64987177 countsByYear W649871772019 @default.
- W64987177 countsByYear W649871772022 @default.
- W64987177 crossrefType "journal-article" @default.
- W64987177 hasAuthorship W64987177A5007689245 @default.
- W64987177 hasAuthorship W64987177A5015340719 @default.
- W64987177 hasConcept C104317684 @default.
- W64987177 hasConcept C153911025 @default.
- W64987177 hasConcept C167625842 @default.
- W64987177 hasConcept C17991360 @default.
- W64987177 hasConcept C187882448 @default.
- W64987177 hasConcept C18903297 @default.
- W64987177 hasConcept C203014093 @default.
- W64987177 hasConcept C2777510941 @default.
- W64987177 hasConcept C2777704720 @default.
- W64987177 hasConcept C2780545260 @default.
- W64987177 hasConcept C2910798392 @default.
- W64987177 hasConcept C505870484 @default.
- W64987177 hasConcept C518008717 @default.
- W64987177 hasConcept C55493867 @default.
- W64987177 hasConcept C86803240 @default.
- W64987177 hasConceptScore W64987177C104317684 @default.
- W64987177 hasConceptScore W64987177C153911025 @default.
- W64987177 hasConceptScore W64987177C167625842 @default.
- W64987177 hasConceptScore W64987177C17991360 @default.
- W64987177 hasConceptScore W64987177C187882448 @default.
- W64987177 hasConceptScore W64987177C18903297 @default.
- W64987177 hasConceptScore W64987177C203014093 @default.
- W64987177 hasConceptScore W64987177C2777510941 @default.
- W64987177 hasConceptScore W64987177C2777704720 @default.
- W64987177 hasConceptScore W64987177C2780545260 @default.
- W64987177 hasConceptScore W64987177C2910798392 @default.
- W64987177 hasConceptScore W64987177C505870484 @default.
- W64987177 hasConceptScore W64987177C518008717 @default.
- W64987177 hasConceptScore W64987177C55493867 @default.
- W64987177 hasConceptScore W64987177C86803240 @default.
- W64987177 hasIssue "4" @default.
- W64987177 hasLocation W649871771 @default.
- W64987177 hasOpenAccess W64987177 @default.
- W64987177 hasPrimaryLocation W649871771 @default.
- W64987177 hasRelatedWork W1986731810 @default.
- W64987177 hasRelatedWork W2016193721 @default.
- W64987177 hasRelatedWork W2037816845 @default.
- W64987177 hasRelatedWork W2162541343 @default.
- W64987177 hasRelatedWork W2466720958 @default.
- W64987177 hasRelatedWork W2766193955 @default.
- W64987177 hasRelatedWork W4236819841 @default.
- W64987177 hasRelatedWork W4240743129 @default.
- W64987177 hasRelatedWork W2185389366 @default.
- W64987177 hasRelatedWork W2548937338 @default.
- W64987177 hasVolume "65" @default.
- W64987177 isParatext "false" @default.
- W64987177 isRetracted "false" @default.