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• W650394422 abstract "Approximately half of patients with muscle invasive bladder cancer succumb to their disease. Previous work identified cell cycle related genes as a prognostic class of gene expression biomarkers in bladder cancer and found a specific 31-gene cell cycle proliferation (CCP) signature predicted outcome across multiple bladder cancer cohorts. However, the prognostic value of the CCP signature specifically in muscle invasive tumors was not evaluated.To determine the prognostic value of cycle related genes in patients with muscle invasive bladder cancers.We collected all publicly available gene expression data for patients with high-grade, muscle invasive bladder cancer (8 cohorts, N = 458). We evaluated the CCP signature and two larger cell cycle gene sets: 1826 genes with a Gene Ontology (GO) annotation of cell cycle (GO-CCS) and 124 genes belonging to the cell cycle pathway in the KEGG pathway database (KEGG-CCS). An independently derived a sex identification gene signature (SIS) was developed as a positive control.While SIS distinguished males from females in all cohorts with information about patient sex, the CCP signature was not prognostic in any of the cohorts we analyzed, and the GO-CCS and KEGG-CCS were never prognostic in more than 2 independent cohorts. Furthermore, neither the CCP, GO-CCS, nor KEGG-CCS signatures were consistently enriched in prognostic genes while SIS was enriched with genes associated with sex in all cohorts.Our findings suggest that cell cycle related genes have limited prognostic value in patients with high-grade, muscle invasive tumors. Their usefulness in predicting progression of noninvasive disease and patient response to chemotherapy remains to be determined." @default.
• W650394422 created "2016-06-24" @default.
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• W650394422 date "2015-04-30" @default.
• W650394422 modified "2023-10-16" @default.
• W650394422 title "The Prognostic Value of Cell Cycle Gene Expression Signatures in Muscle Invasive, High-Grade Bladder Cancer" @default.
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• W650394422 doi "https://doi.org/10.3233/blc-150012" @default.
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