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• W650896511 abstract "In the present study, the effect of thyroid hormone on the release of I131 from the thyroid gland was investigated to evaluate the “Feed-back relation of pituitary-thyroid axis.” The results were summarized as follows.Experimental studies : In normal rabbits, the release of thyroidal I131 was promptly and completely inhibited by a single subcutaneous injection of L-thyroxine (T4) (50μg or 100μg) or 3, 5, 3 triiodo-L-thyronine (T3) (10μg or 50μg).However, the same animals showed no marked inhibition following administration of KI in doses equivalent to the iodine contents of T4.Following administration of TSH (10-30 Ms.E. every twelve hours for one day), the rate of release of thyroidal I131 was increased to similar level that was seen in normal, even in animals of which the I131 release had been inhibited by T4 injection.The release of thyroidal I131 in the hypophysectomized rabbit maintained with TSH administration (5 Ms. E. every twelve hours) showed no marked inhibition by T4 injection.The release of thyroidal I131 in the adrenectomized rabbit maintained with cortisone (0.5-1mg daily) showed marked inhibition by T4 injection, as was observed in normal animal.From these data, it may be concluded that the inhibitory effect of T4 upon the release of thyroidal I131 was chiefly due to the suppression of endogenous TSH secretion.Clinical studies : In normal subjects, a single subcutaneous injection of T4 (1 or 3 mg) caused complete inhibition of the release of thyroidal I131 and increase of PBI level. On the contrary, most patients with hyperthyroidism, even in euthyroid stage, failed to show the inhibitory action of T4 on the release of thyroidal I131In normal subjects who showed an increase of PBI more than about 2μg/dl twenty-four hours after T4 administration, the percent change of the release rate of thyroidal I131 was found to be snore than about 60%, independent of the amount of increase in PBI. Whereas the percent change of the release rate of thyroidal I131 in hyperthyroid patients who showed a relatively small increase of PBI after T4 administration, was found to be less than those of normal subjects with the same amount of increase in PBI. In hyperthyroid patients who showd a larger increase of PBI, the percent change of the release rate of thyroidal I131 was correlated to the amount of increase in PBI, except a few cases (r=+ 0.50, P<0.02).From these data, it was demonstrated that the mesurements of the release rate of thyroidal I131 and of PBI after T4 administration were very excellent aids to evaluate the “Feed-back relation” (Feed-back test).In addition to this test (Feed-back test), other thyroidal function tests were also studied in most cases.As no correlation was found among the “Feed-back index” (the ratio of percent change of release rate of thyroidal I131 to increase amount of PBI), PBI, BMR, I131-uptake and exophthalmometry, these items seemed to show different aspects of thyroidal function.By summarizing these data of the “Feed-back test, ” serum TSH level and TSH-test, the author presented a hypothetical schema of the “Feed-back relation of pituitary-thyroid axis” in hyperthyroidism." @default.
• W650896511 created "2016-06-24" @default.
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• W650896511 date "1960-01-01" @default.
• W650896511 modified "2023-09-25" @default.
• W650896511 title "Studies on the “Feed-back Relation of Pituitary-thyroid Axis”" @default.
• W650896511 doi "https://doi.org/10.1507/endocrine1927.36.4_589" @default.
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