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- W65095667 abstract "Aldose reductase (AR) is a member of the aldo-keto reductase superfamily. It was initially discovered in the seminal vesicles, where it is believed to catalyze the NADPH-mediated reduction of glucose to sorbitol-which in turn is metabolized to fructose required for spermatogenesis (for review see Bhatnagar and Srivastava, 1992). The conversion of glucose to fructose via sorbitol, or the so called polyol pathway was later identified in several other tissues and AR was found to be universally expressed in most tissues examined and in species ranging from yeast to man. Based on the observations that high concentration of polyols accumulate during sugar cataractogenesis, it was suggested that during hyperglyce- mia, the flux of glucose via the polyol pathway is increased and that due to the low permeability of the membrane to polyols, sugar alcohols accumulate in diabetic tissues leading to marked hydration, cell swelling and lysis (Kinoshita and Nishimura, 1988)." @default.
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- W65095667 date "1999-01-01" @default.
- W65095667 modified "2023-10-14" @default.
- W65095667 title "Regulation of Aldose Reductase by Aldehydes and Nitric Oxide" @default.
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- W65095667 doi "https://doi.org/10.1007/978-1-4615-4735-8_63" @default.
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