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- W65134066 abstract "Rabbit head bobs and rodent head twitches are behavioral assays of serotonin (5-HT)2A receptor activation; each behavior can be elicited by DOI (a 5-HT2A/2C agonist) and attenuated by ketanserin (a 5-HT2A antagonist). 5-HT2A receptor antagonists M100907 (M100) and MDL11939 (MDL) also elicit head bobs; however, these effects are distinguishable from DOI-elicited responses as they are not blocked by ketanserin, suggesting a mechanism other than 5-HT2A receptor activation. The current study examined the potential role of 5-HT2C and dopamine (DA) receptors in inducing head bobs. Pre-administration of the 5-HT2C antagonist, SB242084 (1umol/kg, sc, 30 min) reduced head bobs elicited by both M100 (2.5umol/kg) and MDL (3umol/kg). Pretreatment of rabbits with the D1 antagonist SCH23390 (0.05umol/kg) also blocked M100 and MDL elicited head bobs. Moreover, administration of a D1 agonist, SKF38393 (9umol/kg) increased head bobs. To further characterize the role of 5-HT2C receptors, we tested the response to a 5-HT2C inverse agonist, SB206553. At a dose of 1umol/kg, we found no effect; however, a higher dose (3umol/kg) significantly increased head bobs. Consequently, head bobs may be considered an in vivo measure of 5-HT2C inverse agonism. Finally, given the role of 5-HT in DA release, we conclude that SB206553, M100, and MDL all induce the same behavior through 5-HT2C inverse agonist-mediated activation of D1 receptors." @default.
- W65134066 created "2016-06-24" @default.
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- W65134066 date "2010-04-01" @default.
- W65134066 modified "2023-10-16" @default.
- W65134066 title "Serotonin 2C (5‐HT2C) receptor inverse agonists elicit head bob behavior through a dopamine D1 receptor dependent mechanism" @default.
- W65134066 doi "https://doi.org/10.1096/fasebj.24.1_supplement.766.7" @default.
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