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• W65163315 abstract "Autophagy is a dynamic process in which cellular proteins and cytoplasmic organelles are degraded and recycled. Basal autophagy in the heart is important for normal heart functions, but excessive autophagy can be triggered in response to cellular stresses and cardiovascular diseases, and may eventually lead to cell death if the cell is unable to recover. Autophagy can be a survival mechanism for some cancers, and several clinical studies are now exploring autophagy inhibition with chemotherapy as a combination strategy. Several frontline cancer therapeutic agents cause cardiotoxicity by modulating autophagic activities in the heart. Despite the advances in cancer, autophagy, and cardiovascular diseases, cancer treatment without cardiac injury during chemotherapy remains a challenge. The mechanisms of drug action that signal for autophagy need to be better understood to allow detecting and leveraging autophagic outcomes towards cardioprotection. In principle, early detection of autophagy under cardiotoxic conditions may help to prevent severe cumulative heart injury. Several new cardiotoxicity biomarkers have been proposed, but there remains a need for a robust and specific marker that would facilitate early intervention. We review studies measuring autophagy in cardiac tissue and examine their potential to indicate early cardiotoxicity. Much of the data involving autophagy-based biomarkers and cardiotoxicity are based on in vitro studies, which may not always reflect a physiologically complete experimental model for preclinical and clinical translation. Limited studies have been performed in vivo to correlate drug-induced cardiotoxicity with autophagy. This chapter will highlight recent progress with the in vivo assessment of survival-associated autophagy, autophagy-based protein biomarkers for the early detection of cardiotoxicity, and autophagy-based chemotherapeutic approaches for cardioprotection that have been tested in preclinical experimental systems." @default.
• W65163315 created "2016-06-24" @default.
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• W65163315 date "2014-01-01" @default.
• W65163315 modified "2023-09-25" @default.
• W65163315 title "Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy" @default.
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• W65163315 doi "https://doi.org/10.1016/b978-0-12-405529-2.00019-6" @default.
• W65163315 hasPublicationYear "2014" @default.
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