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• W651961654 abstract "Bile acids have been linked to the etiology of colon cancer in various studies for over twenty-five years. However, the mechanism by which bile acids act in colon carcinogenesis is not known. By using an assay that can detect induction of the gaddl53 su'ess response to DNA damage I found that bile acids activate expression of gaddl53 promoter. This observation implies that biie acids cause DNA damage. I then hypothesized that exposure of ceils to biie acids produces reactive oxygen species which damage DNA. However, experiments to block gaddi53 induction by biie acids using antioxidants, and to measure 8-OH-dG induced by bile acids were inconclusive. 1 also used p55 mutant cell lines to show that bile acid induction of apoptosis is p55-independent. In addition, my experiments showed thai biie acid increased expression of gaddl53 protein in HT-29 ceils, and that gaddl 53 protein was constitutively overexpressed in HCT-116 cells with or without bile acid treatment. Thus, biie acid action in colon carcinogenesis may involve induction of DNA damage, induction of gaddl53 as a protective stress response, and then if the damage is beyond repair. p53-independent apoptosis." @default.
• W651961654 created "2016-06-24" @default.
• W651961654 creator A5088345124 @default.
• W651961654 date "1998-01-01" @default.
• W651961654 modified "2023-09-27" @default.
• W651961654 title "Oxidative DNA damage and apoptosis induced by bile acid: Relevance to colon cancer" @default.
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• W651961654 hasPublicationYear "1998" @default.
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