Matches in SemOpenAlex for { <https://semopenalex.org/work/W652021775> ?p ?o ?g. }
- W652021775 endingPage "48" @default.
- W652021775 startingPage "43" @default.
- W652021775 abstract "Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol's effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions." @default.
- W652021775 created "2016-06-24" @default.
- W652021775 creator A5004024773 @default.
- W652021775 creator A5008168090 @default.
- W652021775 creator A5035707420 @default.
- W652021775 creator A5043424443 @default.
- W652021775 creator A5058727304 @default.
- W652021775 creator A5064717294 @default.
- W652021775 creator A5068641506 @default.
- W652021775 creator A5071672663 @default.
- W652021775 creator A5087125305 @default.
- W652021775 date "2015-09-01" @default.
- W652021775 modified "2023-09-27" @default.
- W652021775 title "Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice" @default.
- W652021775 cites W1964356870 @default.
- W652021775 cites W1967850881 @default.
- W652021775 cites W1975478258 @default.
- W652021775 cites W1976654114 @default.
- W652021775 cites W1985201308 @default.
- W652021775 cites W1987713972 @default.
- W652021775 cites W1988094282 @default.
- W652021775 cites W1995472021 @default.
- W652021775 cites W2006533548 @default.
- W652021775 cites W2020262086 @default.
- W652021775 cites W2026650728 @default.
- W652021775 cites W2044666581 @default.
- W652021775 cites W2051749233 @default.
- W652021775 cites W2057090283 @default.
- W652021775 cites W2070388732 @default.
- W652021775 cites W2073263307 @default.
- W652021775 cites W2077825073 @default.
- W652021775 cites W2082029763 @default.
- W652021775 cites W2088443320 @default.
- W652021775 cites W2119515450 @default.
- W652021775 cites W2124029073 @default.
- W652021775 cites W2129328978 @default.
- W652021775 cites W2132401869 @default.
- W652021775 cites W2136052345 @default.
- W652021775 cites W2145462632 @default.
- W652021775 cites W2150669985 @default.
- W652021775 cites W2154947537 @default.
- W652021775 cites W2155547066 @default.
- W652021775 cites W2156525348 @default.
- W652021775 doi "https://doi.org/10.1016/j.fitote.2015.06.002" @default.
- W652021775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26051087" @default.
- W652021775 hasPublicationYear "2015" @default.
- W652021775 type Work @default.
- W652021775 sameAs 652021775 @default.
- W652021775 citedByCount "24" @default.
- W652021775 countsByYear W6520217752016 @default.
- W652021775 countsByYear W6520217752017 @default.
- W652021775 countsByYear W6520217752018 @default.
- W652021775 countsByYear W6520217752019 @default.
- W652021775 countsByYear W6520217752020 @default.
- W652021775 countsByYear W6520217752021 @default.
- W652021775 countsByYear W6520217752022 @default.
- W652021775 crossrefType "journal-article" @default.
- W652021775 hasAuthorship W652021775A5004024773 @default.
- W652021775 hasAuthorship W652021775A5008168090 @default.
- W652021775 hasAuthorship W652021775A5035707420 @default.
- W652021775 hasAuthorship W652021775A5043424443 @default.
- W652021775 hasAuthorship W652021775A5058727304 @default.
- W652021775 hasAuthorship W652021775A5064717294 @default.
- W652021775 hasAuthorship W652021775A5068641506 @default.
- W652021775 hasAuthorship W652021775A5071672663 @default.
- W652021775 hasAuthorship W652021775A5087125305 @default.
- W652021775 hasConcept C126322002 @default.
- W652021775 hasConcept C181199279 @default.
- W652021775 hasConcept C185592680 @default.
- W652021775 hasConcept C2777820942 @default.
- W652021775 hasConcept C2778102346 @default.
- W652021775 hasConcept C2779721657 @default.
- W652021775 hasConcept C2779881121 @default.
- W652021775 hasConcept C2780026642 @default.
- W652021775 hasConcept C2780261098 @default.
- W652021775 hasConcept C2780306776 @default.
- W652021775 hasConcept C2780402116 @default.
- W652021775 hasConcept C55493867 @default.
- W652021775 hasConcept C71924100 @default.
- W652021775 hasConcept C98274493 @default.
- W652021775 hasConceptScore W652021775C126322002 @default.
- W652021775 hasConceptScore W652021775C181199279 @default.
- W652021775 hasConceptScore W652021775C185592680 @default.
- W652021775 hasConceptScore W652021775C2777820942 @default.
- W652021775 hasConceptScore W652021775C2778102346 @default.
- W652021775 hasConceptScore W652021775C2779721657 @default.
- W652021775 hasConceptScore W652021775C2779881121 @default.
- W652021775 hasConceptScore W652021775C2780026642 @default.
- W652021775 hasConceptScore W652021775C2780261098 @default.
- W652021775 hasConceptScore W652021775C2780306776 @default.
- W652021775 hasConceptScore W652021775C2780402116 @default.
- W652021775 hasConceptScore W652021775C55493867 @default.
- W652021775 hasConceptScore W652021775C71924100 @default.
- W652021775 hasConceptScore W652021775C98274493 @default.
- W652021775 hasFunder F4320321001 @default.
- W652021775 hasLocation W6520217751 @default.
- W652021775 hasLocation W6520217752 @default.
- W652021775 hasOpenAccess W652021775 @default.