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- W65205327 abstract "Histamine is produced within the vascular wall and mediates a variety of normal and pathologic vascular responses. The interaction of histamine with its vascular cell receptors has been shown to affect factors such as actin cable formation, cyclase activities, prostacyclin synthesis, cell motility, and proliferation. In addition, abundant evidence exists to implicate an arterial nascent histamine pool in the control of vessel wall permeability under conditions of stress and injury. However, endothelial and smooth muscle cell histamine receptors have been only incompletely characterized. The authors report here the time-dependent, saturable, and trypsin sensitive binding of /sup 3/H-histamine to the endothelial cell surface. The K/sub d/ for endothelial and smooth muscle cell histamine receptors are 0.70 and 2.80 ..mu..M respectively. Histamine binding to smooth muscle cells also exhibited saturation with concentrations of /sup 3/H-histamine up to 4 ..mu..M. While the smooth muscle cell H/sub 1/ receptor binding was negligible, the H/sub 2/ receptor appeared to represent a relatively low affinity, high capacity site for histamine binding. The uptake of /sup 3/H-histamine in both cell types displayed kinetics consistent with that of fluid-phase pinocytosis." @default.
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- W65205327 date "1986-03-01" @default.
- W65205327 modified "2023-09-23" @default.
- W65205327 title "Endothelial and smooth muscle histamine receptors" @default.
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