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- W65322413 abstract "Biomarkers are characteristics that are objectively measured and evaluated as indicators of normal or pathogenic biologic processes. There are a multitude of ways that biomarkers are used including diagnosis of disease, prognosis of clinical outcomes, patient staging and treatment selection, indication of response to a prior natural exposure, and characterization of response to a biomedical intervention. In the general setting of vaccine trials for infectious diseases, the identification of biomarkers ultimately depends on the specifics of the vaccine and the pathogen and typically focuses on aspects of the immune response to vaccine and/or detection and typing of the pathogen. A central use of immune response biomarkers in vaccine research is as primary endpoints for early phase vaccine trials. At one end of the spectrum, these biomarkers define the extent to which the vaccine is biologically active while at the other end they characterize the nature of the response with sufficient detail to provide some sense of the plausibility that the responses would be clinically protective." @default.
- W65322413 created "2016-06-24" @default.
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- W65322413 date "2012-11-19" @default.
- W65322413 modified "2023-10-02" @default.
- W65322413 title "On the Use of Biomarkers in Vaccine Research and Development" @default.
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- W65322413 doi "https://doi.org/10.1007/978-1-4614-5245-4_3" @default.
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