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- W653580821 abstract "Virus-specific enzymes essential for viral nucleic acid replication or related functions are targets for inhibition by substrate or product nucleotide analogues in which one or more P-O bonds are replaced by a P-C bond. The simplest examples of these are PFA (phosphonoformic acid) and PAA (phosphonoacetic acid), representing analogues of 'pyrophosphate' moieties in nucleotides. The synthesis of a series of α-halogenated and α-oxo PAA and MDP (methanediphosphonate) derivatives is described and structure/activity relationships in their inhibition of several human (α,β,γ) and viral (HSV, EBV, HIV) DNA polymerases are presented. Inhibition of HIV RNA-directed DNA polymerase (reverse transcriptase) by PFA, α-oxophosphonoacetate and α-oxomethanediphosphonate is shown to be pH-and template-dependent. Combination of phosphonoacetate derivatives and anti-viral nucleosides into 'hybrid' nucleotide analogues is briefly discussed." @default.
- W653580821 created "2016-06-24" @default.
- W653580821 date "1989-08-22" @default.
- W653580821 modified "2023-10-07" @default.
- W653580821 title "Nucleotide Analogues as Antiviral Agents" @default.
- W653580821 doi "https://doi.org/10.1021/bk-1989-0401" @default.
- W653580821 hasPublicationYear "1989" @default.
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