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- W654052786 abstract "Extensive studies have shown that undifferentiated cellular components of human bone marow are involved in the formation and renewal of bone tissue (osteogenic cascade). In this study, human mesenchymal stem cells were stimulated by bFGF, IGFI, PDGF-BB or TGF-s1, in 2 different concentrations respectively (1 and 10 µg/mL). in vitro to assess their influence on differentiation to the osteoblastic phenotype. Thus human marrow could be used as a malleable basic element in bone engineering. The study clearly showed a stimulatory or suppressive effect of each of the respective growth factors. In particular the addition of TGF-s1 directed the differentiation of mesenchymal stem cells of human bone marrow toward the osteoblastic phenotype." @default.
- W654052786 created "2016-06-24" @default.
- W654052786 creator A5069013936 @default.
- W654052786 date "2008-05-08" @default.
- W654052786 modified "2023-09-27" @default.
- W654052786 title "The Role of bFGF, IGF-I, PDGF and TGF-ß in the Expression of the Osteogenic Phenotype in Human Marrow-Derived Bone-Like Cells In Culture" @default.
- W654052786 hasPublicationYear "2008" @default.
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