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• W654142497 abstract "X-ray fluorescence techniques have proven beneficial for identifying and quantifyingtrace elements in biological tissues. A novel approach has been developed that employsx-ray fluorescence with an aim to locate the presence of nanoparticles, such as gold,which are embedded into tissues. The nanoparticles can be functionalised to act asmarkers for tumour characteristics to map the disease state, and then imaged to informcancer therapy regimes. The uptake of nanoparticles by cancer cells could also enabledetection of small clusters of infiltrating cancer cells which are currently missed bycommonly used imaging modalities. The novel system, consisting of an energyresolving silicon drift detector with high spectral resolution, and a synchrotron source,showed potential in both quantification of and sensitivity to nanoparticle concentrationstypically found in tumours. A linear relationship between fluorescence intensity andnanoparticle concentration was found down to 0.001 mgAu/ml, the detection limit ofthe system. A successful translation using a more clinically available bench-top x-raytube was demonstrated, and found not to degrade the linearity or detection limit. Theachieved system sensitivity suggests clinical usefulness in measuring tumour uptake invivo. A set of bio-phantoms consisting of collagen type 1 gel, populated with colorectalcancer cells (HT29) and healthy murine fibroblast cells (3T3) that have been incubatedwith gold nanoparticles (GNPs), were created. The bio-samples were successfully usedto (i) demonstrate GNP uptake in cells, and (ii) demonstrate the use of the novel benchtopsystem in measuring GNP uptake in cells. Translation to a 2D imaging techniquewas undertaken, using polycapillary optic technology to acquire positional informationof gold XRF emissions, and energy resolving single channel and pixellated detectors.The GNP-imaging capabilities of the XRF technique were demonstrated using Perspexphantoms incorporating different GNP concentrations. Details of phantoms withconcentrations as low as 0.025 mgAu/ml have been successfully imaged, with potentialto image lower concentrations. It can be inferred from feasibility data collected that thex-ray fluorescence technique can be combined with x-ray diffraction methods to form anovel multi-modality system that is sensitive to GNP distribution and can discriminatebiological tissue. Future work will develop this combined system to locate tumours andprovide information on tumour characteristics." @default.
• W654142497 created "2016-06-24" @default.
• W654142497 creator A5074015191 @default.
• W654142497 date "2012-03-28" @default.
• W654142497 modified "2023-09-23" @default.
• W654142497 title "Nanoparticles for tumour diagnostics" @default.
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