Matches in SemOpenAlex for { <https://semopenalex.org/work/W65415065> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W65415065 endingPage "9" @default.
- W65415065 startingPage "114" @default.
- W65415065 abstract "The effects of suboptimal levels of zinc, an essential trace element, on the ability of murine macrophages to associate with and destroy a pathogenic parasite, Trypanosoma cruzi, were evaluated. Young adult A/J mice were fed zinc-deficient, zinc-adequate or restricted amounts of a zinc-adequate diet for 28 days. On the basis of weight loss and parakeratosis, the zinc-deficient mice were further divided into moderately and severely zinc-deficient on Day 28. Both the percentage of mouse peritoneal macrophages (MPM) with associated parasites and the number of parasites per 100 macrophages were significantly lower for macrophages from moderately and severely deficient mice compared to MPM from mice fed restricted or zinc-adequate diet. Furthermore, MPM from both zinc-deficient groups of mice killed fewer internalized parasites than did MPM from restricted or zinc-adequate mice. Pretreatment of MPM from zinc-deficient mice with 5 micrograms zinc/ml for 30 min completely restored both their capacity to take up and kill the parasites. Other trace metals tested, including copper, manganese and nickel, failed to reverse the effects of zinc deficiency. These results point to an important role for zinc in the biochemical events associated with macrophage uptake and killing of the parasite." @default.
- W65415065 created "2016-06-24" @default.
- W65415065 creator A5013151184 @default.
- W65415065 creator A5022617720 @default.
- W65415065 creator A5082634942 @default.
- W65415065 date "1989-09-01" @default.
- W65415065 modified "2023-10-18" @default.
- W65415065 title "Zinc requirement for macrophage function: effect of zinc deficiency on uptake and killing of a protozoan parasite." @default.
- W65415065 cites W1508909031 @default.
- W65415065 cites W1602708296 @default.
- W65415065 cites W1642046246 @default.
- W65415065 cites W1858270401 @default.
- W65415065 cites W1896946344 @default.
- W65415065 cites W1950719471 @default.
- W65415065 cites W1960937410 @default.
- W65415065 cites W1974401900 @default.
- W65415065 cites W1979966330 @default.
- W65415065 cites W1989437103 @default.
- W65415065 cites W2003009751 @default.
- W65415065 cites W2035203209 @default.
- W65415065 cites W2059719837 @default.
- W65415065 cites W2083375040 @default.
- W65415065 cites W2113905385 @default.
- W65415065 cites W2160040629 @default.
- W65415065 cites W2204627580 @default.
- W65415065 cites W2332380136 @default.
- W65415065 cites W2341278415 @default.
- W65415065 cites W2418387071 @default.
- W65415065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1385514" @default.
- W65415065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2680908" @default.
- W65415065 hasPublicationYear "1989" @default.
- W65415065 type Work @default.
- W65415065 sameAs 65415065 @default.
- W65415065 citedByCount "34" @default.
- W65415065 countsByYear W654150652012 @default.
- W65415065 countsByYear W654150652013 @default.
- W65415065 countsByYear W654150652014 @default.
- W65415065 countsByYear W654150652015 @default.
- W65415065 countsByYear W654150652016 @default.
- W65415065 countsByYear W654150652017 @default.
- W65415065 countsByYear W654150652018 @default.
- W65415065 countsByYear W654150652019 @default.
- W65415065 countsByYear W654150652021 @default.
- W65415065 countsByYear W654150652022 @default.
- W65415065 countsByYear W654150652023 @default.
- W65415065 crossrefType "journal-article" @default.
- W65415065 hasAuthorship W65415065A5013151184 @default.
- W65415065 hasAuthorship W65415065A5022617720 @default.
- W65415065 hasAuthorship W65415065A5082634942 @default.
- W65415065 hasConcept C136764020 @default.
- W65415065 hasConcept C178790620 @default.
- W65415065 hasConcept C185592680 @default.
- W65415065 hasConcept C202751555 @default.
- W65415065 hasConcept C203014093 @default.
- W65415065 hasConcept C2776928490 @default.
- W65415065 hasConcept C2777625466 @default.
- W65415065 hasConcept C2779244956 @default.
- W65415065 hasConcept C41008148 @default.
- W65415065 hasConcept C535196362 @default.
- W65415065 hasConcept C55493867 @default.
- W65415065 hasConcept C71928629 @default.
- W65415065 hasConcept C86803240 @default.
- W65415065 hasConcept C89423630 @default.
- W65415065 hasConceptScore W65415065C136764020 @default.
- W65415065 hasConceptScore W65415065C178790620 @default.
- W65415065 hasConceptScore W65415065C185592680 @default.
- W65415065 hasConceptScore W65415065C202751555 @default.
- W65415065 hasConceptScore W65415065C203014093 @default.
- W65415065 hasConceptScore W65415065C2776928490 @default.
- W65415065 hasConceptScore W65415065C2777625466 @default.
- W65415065 hasConceptScore W65415065C2779244956 @default.
- W65415065 hasConceptScore W65415065C41008148 @default.
- W65415065 hasConceptScore W65415065C535196362 @default.
- W65415065 hasConceptScore W65415065C55493867 @default.
- W65415065 hasConceptScore W65415065C71928629 @default.
- W65415065 hasConceptScore W65415065C86803240 @default.
- W65415065 hasConceptScore W65415065C89423630 @default.
- W65415065 hasIssue "1" @default.
- W65415065 hasLocation W654150651 @default.
- W65415065 hasOpenAccess W65415065 @default.
- W65415065 hasPrimaryLocation W654150651 @default.
- W65415065 hasRelatedWork W186807232 @default.
- W65415065 hasRelatedWork W1964671957 @default.
- W65415065 hasRelatedWork W1991904065 @default.
- W65415065 hasRelatedWork W1997909771 @default.
- W65415065 hasRelatedWork W2016586610 @default.
- W65415065 hasRelatedWork W2337075798 @default.
- W65415065 hasRelatedWork W2399602398 @default.
- W65415065 hasRelatedWork W2942377989 @default.
- W65415065 hasRelatedWork W4251849287 @default.
- W65415065 hasRelatedWork W65415065 @default.
- W65415065 hasVolume "68" @default.
- W65415065 isParatext "false" @default.
- W65415065 isRetracted "false" @default.
- W65415065 magId "65415065" @default.
- W65415065 workType "article" @default.