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- W654502743 abstract "Manganese is recognized as an essential nutrient for humans and animals; however, in excessive amounts manganese is also a toxic substance. Manganese has been defined as being a component of several enzymes and an activator of several other enzyme systems although other minerals such as magnesium can substitute for manganese in many but not all of these metabolic processes. Since nutritional adequacy of manganese is necessary for the enzyme manganese superoxide dismutase, research dealing with this enzyme is of current interest. Only one case of frank manganese deficiency in the human has been identified and publicized in the literature. However, animal studies indicate that manganese deficiencies affect bone, brain and reproductive systems. Manganese absorption from the gastrointestinal tract is thought to be poor but its absorption is thought to be at least in part governed by its valence state. In the United States recent research suggests that mean manganese intakes of women are considerably lower than are the NRC Estimated Safe and Adequate Daily Dietary Intakes while those of formula fed infants are greater than the NRC ESADDI listings for this age group. Depending upon manganese source and availability of manganese from these sources, manganese adequacy or toxicity might be a problem for these segments of the American population." @default.
- W654502743 created "2016-06-24" @default.
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- W654502743 date "1987-10-05" @default.
- W654502743 modified "2023-10-13" @default.
- W654502743 title "Nutritional Bioavailability of Manganese" @default.
- W654502743 cites W2502661784 @default.
- W654502743 doi "https://doi.org/10.1021/bk-1987-0354" @default.
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