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• W654680404 abstract "In this paper, we have reported seventeen novel synthetic organic compounds derived from marine bromopyrrole alkaloids, exhibiting potential inhibition of biofilm produced by Gram-positive bacteria. Compound 5f with minimumbiofilm inhibitory concentration(MBIC) of 0.39, 0.78 and 3.125 μg/mL against MSSA, MRSA and SE respectively, emerged as promising anti-biofilm lead compounds. In addition, compounds 5b, 5c, 5d, 5e, 5f, 5h, 5i and 5j revealed equal potency as that of the standard drug Vancomycin (MBIC = 3.125 μg/mL) against Streptococcus epidermidis. Notably, most of the synthesized compounds displayed better potency than Vancomycin indicating their potential as inhibitors of bacterial biofilm. The cell viability assay for the most active hybrid confirms its anti-virulence properties which need to be further researched." @default.
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• W654680404 date "2015-08-01" @default.
• W654680404 modified "2023-09-23" @default.
• W654680404 title "Novel synthetic organic compounds inspired from antifeedant marine alkaloids as potent bacterial biofilm inhibitors" @default.
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• W654680404 doi "https://doi.org/10.1016/j.bioorg.2015.06.001" @default.
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