Matches in SemOpenAlex for { <https://semopenalex.org/work/W654860876> ?p ?o ?g. }
- W654860876 abstract "The process of colon carcinogenesis is dependent upon a variety of genetic mutations and intestinal luminal risk factors. These risk factors cooperate to influence pathophysiological targets directly linked to the carcinogenic process. Cyclooxygenase-2 (COX-2) is one such target, and it is found to be upregulated in 50% of colonic adenomas and 85% of carcinomas. The interaction between genetic mutations and luminal risk factors to affect COX-2 expression was explored in this dissertation work. An activated K-ras oncogene and mutant APC tumor suppressor gene both regulate COX-2 posttranscriptionally. Using colon cancer cells with these genetic alterations, we determined that an activated K-ras stabilizes COX-2 mRNA and works through a PKC-dependent mechanism in a cell line-specific manner. K-ras also affected PTEN expression to potentially suppress cell survival. Wild-type APC downregulated COX-2 protein levels without affecting mRNA. APC interfered with PI-3K-dependent signaling of COX-2, and affected PKC-depending signaling to further modulate COX-2 expression. In addition to genetic alterations, luminal factors obtained from the diet influenced COX-2 expression in these colon cancer cell models. Secondary bile acids like deoxycholic acid (DCA) mediated COX-2 protein stability in addition to its known affects on transcription. DCA's affects on COX-2 protein were partially mediated by APC mutational status and PKC-signaling. Polyamines, another luminal risk factor for colon cancer, regulated COX-2 through the induction of RNA processing by the" @default.
- W654860876 created "2016-06-24" @default.
- W654860876 creator A5062217156 @default.
- W654860876 date "2002-01-01" @default.
- W654860876 modified "2023-09-23" @default.
- W654860876 title "The effects of genetic and luminal risk factors on cyclooxygenase-2 expression in human colon cancer cells" @default.
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