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- W65523742 abstract "Evidence has been obtained that cellular receptors for the Amadori product fructosyllysine are important for the development of diabetic vascular complications. Binding studies with glycated albumin and glycated LDL and competition experiments have demonstrated that the binding proteins (100 and 200 kDa) recognize fructosyllysine as binding epitope rather than an Amadori-modified amino acid sequences or AGE. The 100 kDa receptor protein is nucleolin-like. Ligand binding to monocytes induced a release of the cytokines IL-1β and TNF-α. Receptor expression varies from individual to individual. But it is neither age nor sex dependent. It is associated with some indices of diabetic microangiopathy, such as capillary basement membrane thickening." @default.
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- W65523742 date "2005-01-01" @default.
- W65523742 modified "2023-10-16" @default.
- W65523742 title "Cellular Receptors for N ɛ –Fructosyllysine: Potential Role in the Development of Diabetic Microangiopathy" @default.
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- W65523742 doi "https://doi.org/10.1533/9781845698447.7.369" @default.
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