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- W655894225 abstract "The metabolic regulatory role of AMPK is well established but potential mechanisms of AMPK in vascular control are not well defined. Aortic rings were isolated from 16–20wk old male SHR and WKY rats and assessed using myography to determine potential vasomotor effects of AICAR. There was a significant drop in resting tension after endothelium-denuded rings were incubated with AICAR (A; 2mM, 30 min) in SHR (control (C) = −0.14±0.06g, A = −0.97±0.09g, p<0.01) but not in WKY vessels (C = −0.26±0.06g, A = −0.24±0.08g, p=NS, strain*drug p<0.01). Both SHR and WKY denuded vessels relaxed upon exposure to AICAR following phenylephrine pre-constriction (PE 10−7M; SHR: C = 2.1±2.2%, A = 41.4±11.9%, p<0.01; WKY: C = 3.0±2.2%, A = 23.7±9.7%, p<0.01). In denuded vessels pre-exposed to AICAR, potassium chloride dose-response curves were right-shifted in both SHR and WKY (SHR C vs A p<0.01, WKY C vs A p<0.01) and developed tension to increasing PE concentrations was blunted in both strains at all concentrations (max tension SHR: C = 2.07±0.19g, A = 1.14±0.21g, p<0.01; WKY: C = 2.57±0.19g, A = 1.98±0.21g, p<0.01, strain*drug p<0.01). These results suggest that AMPK can influence vasomotor function in SHR and WKY aortic rings. Funded by the Heart and Stroke Foundation of Ontario" @default.
- W655894225 created "2016-06-24" @default.
- W655894225 creator A5003961563 @default.
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- W655894225 date "2008-03-01" @default.
- W655894225 modified "2023-10-16" @default.
- W655894225 title "AMP Kinase (AMPK) activator 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside (AICAR) alters vascular smooth muscle vasomotor responses in thoracic aorta rings from spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats" @default.
- W655894225 doi "https://doi.org/10.1096/fasebj.22.1_supplement.965.6" @default.
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