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• W655928414 abstract "The abuse of opiates such as morphine in synergy with HIV infection accelerates neurocognitive impairments and neuropathology in the CNS of HIV-infected subjects, collectively referred to as HAND. To identify potential pathogenic markers associated with HIV and morphine in perturbing the synaptic architecture, we performed quantitative mass spectrometry proteomics on purified synaptosomes isolated from the caudate of two groups of rhesus macaques chronically infected with SIV differing by one regimen-morphine treatment. The upregulation of heat shock 70-kDa protein 5 in the SIV + morphine group points to increased cellular stress during SIV/morphine interaction thus leading to CNS dysfunction." @default.
• W655928414 created "2016-06-24" @default.
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• W655928414 date "2015-06-03" @default.
• W655928414 modified "2023-10-18" @default.
• W655928414 title "Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse" @default.
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• W655928414 doi "https://doi.org/10.1007/s13365-015-0356-9" @default.
• W655928414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618049" @default.
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