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- W6559404 abstract "The first section of this dissertation describes the synthesis of a tethered macrocyclic ring system based on the natural product westiellamide. As expected, this system was shown to increase the affinity and ease of complexation to Ag(I) ions as confirmed by NMR and fluorescence Ag(I) titration studies.The second section describes the synthesis of a new series of heterocyclic inhibitors of the BoNT serotype A metalloprotease based on the therapeutic lead NSC 240898. Preliminary structure-activity relationship studies afford detailed insights into the steric and lectrostaticproperties of the pharmacophore of this molecular scaffold. Four of the newly synthesized inhibitors exhibited elevated inhibition against BoNT/A LC when compared to the lead agent.The third section describes an approach towards the total synthesis of haouamine A. A promising route to the marine alkaloid was established, including a highly efficient Suzuki crosscouplingreaction, aldol condensation and aromatization reaction. Several late-stage intermediates were analyzed by X-ray diffraction to provide valuable information about the relationships between conformation and reactivity." @default.
- W6559404 created "2016-06-24" @default.
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- W6559404 date "2010-06-28" @default.
- W6559404 modified "2023-09-27" @default.
- W6559404 title "Synthetic Studies on Haouamine A and Other Biologically Active Heterocycles" @default.
- W6559404 hasPublicationYear "2010" @default.
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