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- W6564870 abstract "Muscle fibers are large multinucleated cells whose most obvious histological feature is cross-striations. The cytoplasm contains many myofibrils that include tiny cylinders consisting of bundles of myofilaments. The myofilaments include thick filaments mainly composed of myosin and thin filaments mainly composed of actin. The thick and thin filaments cause the cross-striations because of their regular overlap that is kept in register all across the diameter of the muscle fiber. The A-band corresponds to the thick filament. The I-band forms where the thin filament does not overlap the thick filament. Z-disks are centered in the I-band. The functional unit of contraction is the sarcomere, which extends from one Z-disk to the next. The whole point of muscles is to deliver force to the outside of the muscle. This is accomplished by transferring the force to cytoskeletal elements that connect the internal myofilaments to special proteins that penetrate the membrane. These proteins transfer the force to the extracellular matrix at special regions called costameres. It is found that dystrophin, the protein lacking in some kinds of muscular dystrophy, is concentrated at the costameres." @default.
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- W6564870 date "2012-01-01" @default.
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- W6564870 title "Contractile Mechanisms in Skeletal Muscle" @default.
- W6564870 doi "https://doi.org/10.1016/b978-0-12-382163-8.00028-1" @default.
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