Matches in SemOpenAlex for { <https://semopenalex.org/work/W656844809> ?p ?o ?g. }
- W656844809 endingPage "58" @default.
- W656844809 startingPage "50" @default.
- W656844809 abstract "Adenosine is a pleiotropic endogenous nucleoside with potential neuroprotective pharmacological activity. However, clinical use of adenosine is hampered by its extremely fast metabolization. To overcome this limitation, we recently developed a new squalenoyl nanomedicine of adenosine [Squalenoyl-Adenosine (SQAd)] by covalent linkage of this nucleoside to the squalene, a natural lipid. The resulting nanoassemblies (NAs) displayed a dramatic pharmacological activity both in cerebral ischemia and spinal cord injury pre-clinical models. The aim of the present study was to investigate the plasma profile and tissue distribution of SQAd NAs using both Squalenoyl-[(3)H]-Adenosine NAs and [(14)C]-Squalenoyl-Adenosine NAs as respective tracers of adenosine and squalene moieties of the SQAd bioconjugate. This study was completed by radio-HPLC analysis allowing to determine the metabolization profile of SQAd. We report here that SQAd NAs allowed a sustained circulation of adenosine under its prodrug form (SQAd) for at least 1h after intravenous administration, when free adenosine was metabolized within seconds after injection. Moreover, the squalenoylation of adenosine and its formulation as NAs also significantly modified biodistribution, as SQAd NAs were mainly captured by the liver and spleen, allowing a significant release of adenosine in the liver parenchyma. Altogether, these results suggest that SQAd NAs provided a reservoir of adenosine into the bloodstream which may explain the previously observed neuroprotective efficacy of SQAd NAs against cerebral ischemia and spinal cord injury." @default.
- W656844809 created "2016-06-24" @default.
- W656844809 creator A5000119703 @default.
- W656844809 creator A5000703225 @default.
- W656844809 creator A5005506799 @default.
- W656844809 creator A5007011054 @default.
- W656844809 creator A5010644966 @default.
- W656844809 creator A5013203026 @default.
- W656844809 creator A5018305414 @default.
- W656844809 creator A5029094457 @default.
- W656844809 creator A5029855879 @default.
- W656844809 creator A5033552144 @default.
- W656844809 creator A5035398159 @default.
- W656844809 creator A5043418563 @default.
- W656844809 creator A5055920695 @default.
- W656844809 creator A5076786725 @default.
- W656844809 creator A5078174247 @default.
- W656844809 date "2015-08-01" @default.
- W656844809 modified "2023-09-27" @default.
- W656844809 title "Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis" @default.
- W656844809 cites W1485389808 @default.
- W656844809 cites W1487122482 @default.
- W656844809 cites W1551417600 @default.
- W656844809 cites W1568289572 @default.
- W656844809 cites W1962662176 @default.
- W656844809 cites W1963852088 @default.
- W656844809 cites W1969338731 @default.
- W656844809 cites W1974992332 @default.
- W656844809 cites W1975391500 @default.
- W656844809 cites W1975495109 @default.
- W656844809 cites W1978379381 @default.
- W656844809 cites W1984957474 @default.
- W656844809 cites W1985598247 @default.
- W656844809 cites W2000998413 @default.
- W656844809 cites W2007801077 @default.
- W656844809 cites W2011607679 @default.
- W656844809 cites W2013257758 @default.
- W656844809 cites W2019861549 @default.
- W656844809 cites W2029609295 @default.
- W656844809 cites W2033979758 @default.
- W656844809 cites W2034473036 @default.
- W656844809 cites W2041968066 @default.
- W656844809 cites W2042026130 @default.
- W656844809 cites W2054745605 @default.
- W656844809 cites W2058868308 @default.
- W656844809 cites W2059999322 @default.
- W656844809 cites W2061863138 @default.
- W656844809 cites W2072434736 @default.
- W656844809 cites W2073494047 @default.
- W656844809 cites W2076230055 @default.
- W656844809 cites W2078057254 @default.
- W656844809 cites W2081196843 @default.
- W656844809 cites W2084938226 @default.
- W656844809 cites W2094091345 @default.
- W656844809 cites W2114611409 @default.
- W656844809 cites W2117637600 @default.
- W656844809 cites W2134601695 @default.
- W656844809 cites W2146388330 @default.
- W656844809 cites W2147501312 @default.
- W656844809 cites W2147939962 @default.
- W656844809 cites W2148299677 @default.
- W656844809 cites W2158026247 @default.
- W656844809 cites W2235208690 @default.
- W656844809 cites W2335646063 @default.
- W656844809 cites W2336295169 @default.
- W656844809 cites W2406237301 @default.
- W656844809 doi "https://doi.org/10.1016/j.jconrel.2015.06.016" @default.
- W656844809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4534517" @default.
- W656844809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26087468" @default.
- W656844809 hasPublicationYear "2015" @default.
- W656844809 type Work @default.
- W656844809 sameAs 656844809 @default.
- W656844809 citedByCount "19" @default.
- W656844809 countsByYear W6568448092015 @default.
- W656844809 countsByYear W6568448092016 @default.
- W656844809 countsByYear W6568448092018 @default.
- W656844809 countsByYear W6568448092019 @default.
- W656844809 countsByYear W6568448092020 @default.
- W656844809 countsByYear W6568448092021 @default.
- W656844809 countsByYear W6568448092022 @default.
- W656844809 countsByYear W6568448092023 @default.
- W656844809 crossrefType "journal-article" @default.
- W656844809 hasAuthorship W656844809A5000119703 @default.
- W656844809 hasAuthorship W656844809A5000703225 @default.
- W656844809 hasAuthorship W656844809A5005506799 @default.
- W656844809 hasAuthorship W656844809A5007011054 @default.
- W656844809 hasAuthorship W656844809A5010644966 @default.
- W656844809 hasAuthorship W656844809A5013203026 @default.
- W656844809 hasAuthorship W656844809A5018305414 @default.
- W656844809 hasAuthorship W656844809A5029094457 @default.
- W656844809 hasAuthorship W656844809A5029855879 @default.
- W656844809 hasAuthorship W656844809A5033552144 @default.
- W656844809 hasAuthorship W656844809A5035398159 @default.
- W656844809 hasAuthorship W656844809A5043418563 @default.
- W656844809 hasAuthorship W656844809A5055920695 @default.
- W656844809 hasAuthorship W656844809A5076786725 @default.
- W656844809 hasAuthorship W656844809A5078174247 @default.
- W656844809 hasBestOaLocation W6568448091 @default.