Matches in SemOpenAlex for { <https://semopenalex.org/work/W65712062> ?p ?o ?g. }
- W65712062 endingPage "36" @default.
- W65712062 startingPage "1" @default.
- W65712062 abstract "A large antibody repertoire is generated in developing B cells in the bone marrow. Before these B cells achieve immunocompetence, those expressing autospecificities must be purged. To that end, B cells within the bone marrow and just following egress from the bone marrow are subject to tolerance induction. Once B cells achieve immunocompetence, the antibody repertoire can be further diversified by somatic hypermutation of immunoglobulin genes in B cells that have been activated by antigen and cognate T cell help and have undergone a germinal center (GC) response. This process also leads to the generation of autoreactive B cells which must be again purged to protect the host. Thus, B cells within the GC and just following egress from the GC are also subject to tolerance induction. Available data suggest that B cell intrinsic processes triggered by signaling through the B cell receptor activate tolerance mechanisms at both time points. Recent data suggest that GC and post-GC B cells are also subject to B cell extrinsic tolerance mechanisms mediated through soluble and membrane-bound factors derived from various T cell subsets." @default.
- W65712062 created "2016-06-24" @default.
- W65712062 creator A5049160911 @default.
- W65712062 creator A5089808423 @default.
- W65712062 date "2013-01-01" @default.
- W65712062 modified "2023-09-25" @default.
- W65712062 title "Fate Determination of Mature Autoreactive B Cells" @default.
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