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- W65717035 abstract "61 Objectives The aim of this study was to determine whether PET-MR could predict survival and response in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib. Methods We prospectively recruited 21 advanced HCC patients (M;F18:3,age54±9y) who started to take sorafenib from Oct 2010 to Jul 2011. Before the medication (#1), 2 wks later (#2), 4 wks later (#3), and 8wks later (#4), they underwent parallelly installed PET/CT-MR: whole body FDG PET/CT, liver MR, and delayed liver PET/CT sequentially. MR consisted of T2, diffusion weighted image (b values, 0 and 800 sec/mm2), and dynamic enhanced MRI. Abdomen CT scans were performed at #1 and #4. All patients were analyzed by diverse parameters [maxSUV at early and delayed PET (SUV1h, SUV2h), metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), steepest slope of the enhancement curve (SS) and other clinical parameters]. Treatment response was evaluated according to modified RECIST criteria. A relationship between covariates and survival was analyzed using Kaplan-Meier method and multivariate Cox proportional-hazard regression method. Results The median survival of the 21 patients was 145 days (33-295 days) and there were 1 partial response (PR), 6 stable disease (SD), and 10 progressive disease (PD). MTV#1 was significantly lower in patients with PR or SD (median 56.2) than patients with PD (median 651.8,p Conclusions MTV and ADC measured by PET-MR correlated well with treatment response and overall survival in HCC patients who received sorafenib" @default.
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- W65717035 date "2012-05-01" @default.
- W65717035 modified "2023-09-23" @default.
- W65717035 title "PET-MR can predict survival and response in advanced hepatocellular carcinoma patients treated with sorafenib" @default.
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