Matches in SemOpenAlex for { <https://semopenalex.org/work/W65721812> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W65721812 endingPage "44" @default.
- W65721812 startingPage "35" @default.
- W65721812 abstract "Publisher SummaryOne of the most important functions performed by macrophages during the induction of an immune response may be the presentation of antigen to antibody-forming cell precursors in a molecular form appropriate for cell activation. Antigen that is poorly concentrated by macrophages is often only weakly immunogenic or may induce tolerance instead of immunity. This chapter discusses the role of macrophages in making antigen more immunogenic and less tolerogenic. Antigen persists in a highly immunogenic form on the surface of macrophages in vivo and in vitro. Macrophages may serve to alter antigens to make them more immunogenic, to hold antigens on their surface to focus cell interaction between lymphocytes, and/or to aggregate antigens and remove potentially tolerogenic molecular species. The two crucial roles required for activation of antibody-forming cells are: (1) the uptake of potentially tolerogenic soluble antigen and (2) antigen expression in a cell-bound multivalent complex that is more suitable for immune induction." @default.
- W65721812 created "2016-06-24" @default.
- W65721812 creator A5019314608 @default.
- W65721812 date "1976-01-01" @default.
- W65721812 modified "2023-09-25" @default.
- W65721812 title "The Role of Macrophages in the Specific Determination of Immunogenicity and Tolerogenicity" @default.
- W65721812 cites W135731387 @default.
- W65721812 cites W2002403281 @default.
- W65721812 cites W2015242725 @default.
- W65721812 cites W2018932922 @default.
- W65721812 cites W2020448596 @default.
- W65721812 cites W2027296760 @default.
- W65721812 cites W2055017838 @default.
- W65721812 cites W2056418282 @default.
- W65721812 cites W2066722240 @default.
- W65721812 cites W2086695584 @default.
- W65721812 cites W2110225325 @default.
- W65721812 cites W2118641946 @default.
- W65721812 cites W2127389438 @default.
- W65721812 cites W2133164292 @default.
- W65721812 cites W2144816860 @default.
- W65721812 cites W2152620991 @default.
- W65721812 cites W2161574642 @default.
- W65721812 cites W2221926917 @default.
- W65721812 cites W4313309234 @default.
- W65721812 doi "https://doi.org/10.1016/b978-0-12-514550-3.50008-6" @default.
- W65721812 hasPublicationYear "1976" @default.
- W65721812 type Work @default.
- W65721812 sameAs 65721812 @default.
- W65721812 citedByCount "12" @default.
- W65721812 crossrefType "book-chapter" @default.
- W65721812 hasAuthorship W65721812A5019314608 @default.
- W65721812 hasConcept C159654299 @default.
- W65721812 hasConcept C203014093 @default.
- W65721812 hasConcept C2780868878 @default.
- W65721812 hasConcept C86803240 @default.
- W65721812 hasConceptScore W65721812C159654299 @default.
- W65721812 hasConceptScore W65721812C203014093 @default.
- W65721812 hasConceptScore W65721812C2780868878 @default.
- W65721812 hasConceptScore W65721812C86803240 @default.
- W65721812 hasLocation W657218121 @default.
- W65721812 hasOpenAccess W65721812 @default.
- W65721812 hasPrimaryLocation W657218121 @default.
- W65721812 hasRelatedWork W1548104248 @default.
- W65721812 hasRelatedWork W1552738310 @default.
- W65721812 hasRelatedWork W1556199149 @default.
- W65721812 hasRelatedWork W1606819293 @default.
- W65721812 hasRelatedWork W2079675939 @default.
- W65721812 hasRelatedWork W2403806215 @default.
- W65721812 hasRelatedWork W2428121789 @default.
- W65721812 hasRelatedWork W2467554648 @default.
- W65721812 hasRelatedWork W2470318958 @default.
- W65721812 hasRelatedWork W3042894437 @default.
- W65721812 isParatext "false" @default.
- W65721812 isRetracted "false" @default.
- W65721812 magId "65721812" @default.
- W65721812 workType "book-chapter" @default.