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• W657271497 abstract "To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs.The results revealed significant association with IRF5 (p<0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes.This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A." @default.
• W657271497 created "2016-06-24" @default.
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• W657271497 date "2015-07-01" @default.
• W657271497 modified "2023-10-03" @default.
• W657271497 title "IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups" @default.
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• W657271497 doi "https://doi.org/10.1016/j.humimm.2015.06.001" @default.
• W657271497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26092158" @default.
• W657271497 hasPublicationYear "2015" @default.
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