Matches in SemOpenAlex for { <https://semopenalex.org/work/W65735699> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W65735699 endingPage "6" @default.
- W65735699 startingPage "1491" @default.
- W65735699 abstract "To determine if the anterior uveitis associated with adjuvant arthritis (AA) in the rat can be passively transferred with arthritis to syngeneic recipients using spleen cells or T cell lines prepared from animals given complete Freund's adjuvant (CFA) and Mycobacterium butyricum (M. butyricum) in incomplete Freund's adjuvant (IFA).Spleen cells from Lewis or Lewis SsN rats given IFA, CFA, type I collagen in IFA (CI-IFA), or type II collagen in IFA (CII-IFA) were administered to naive rats or rats treated with pertussis toxin or bacterial endotoxin. Three CD4+ T cell lines, propagated from CFA injected rats and maintained in vitro with M. butyricum (M-1), bovine proteoglycan (PR-1) or an extract of M. butyricum (MBE-1) were administered to naive or immunosuppressed rats. The arthritogenic and uveitogenic properties of these cell preparations and intradermal MBE-IFA, CII-IFA and intraperitoneal (ip) M. butyricum without adjuvant were evaluated.Uveitis was observed in 15/69 (22%) arthritic rats given CFA. Spleen cells prepared from CFA injected rats caused arthritis in 55 (82%) and uveitis in 2 (3%) of 67 cell recipients. Uveitis occurred in 2/6 cell recipients pretreated with bacterial endotoxin. Neither uveitis nor arthritis was observed in rats given IFA (0/6) or spleen cells prepared from rats given IFA (0/27), CI-IFA (0/6), or CII-IFA (0/28). CII-IFA produced polyarthritis in 5/6 rats, but no uveitis. CII-IFA induced arthritis associated uveitis in 1/15 animals receiving spleen cells from rats given CII-IFA, but not those given CI-IFA (0/3) or IFA (0/13). Uveitis was observed in one recipient of the M-1 T cell line and in 2 recipients of the PR-1 T cell line. Immunization with 400 micrograms of MBE-IFA induced uveitis but not arthritis in 3/11 animals. The MBE specific T cell line was neither arthritogenic nor uveitogenic. A high frequency (5/6) of uveitis accompanied arthritis in male Lewis rats given ip M. butyricum. Arthritis occurred in 4/10 female Lewis rats given ip M. butyricum and 2 arthritic animals also developed uveitis.Uveitis occurs infrequently in arthritic rats given spleen cells from CFA injected animals. The ip administration of M. butyricum constitutes a novel disease model in which the immunopathological relationships between arthritis and uveitis may be more reliably studied." @default.
- W65735699 created "2016-06-24" @default.
- W65735699 creator A5001736898 @default.
- W65735699 creator A5004101001 @default.
- W65735699 creator A5011819782 @default.
- W65735699 creator A5012352266 @default.
- W65735699 creator A5036478834 @default.
- W65735699 creator A5084012950 @default.
- W65735699 creator A5090320377 @default.
- W65735699 date "1994-08-01" @default.
- W65735699 modified "2023-09-26" @default.
- W65735699 title "Experimental arthritis and uveitis in rats associated with Mycobacterium butyricum." @default.
- W65735699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7983652" @default.
- W65735699 hasPublicationYear "1994" @default.
- W65735699 type Work @default.
- W65735699 sameAs 65735699 @default.
- W65735699 citedByCount "3" @default.
- W65735699 countsByYear W657356992012 @default.
- W65735699 crossrefType "journal-article" @default.
- W65735699 hasAuthorship W65735699A5001736898 @default.
- W65735699 hasAuthorship W65735699A5004101001 @default.
- W65735699 hasAuthorship W65735699A5011819782 @default.
- W65735699 hasAuthorship W65735699A5012352266 @default.
- W65735699 hasAuthorship W65735699A5036478834 @default.
- W65735699 hasAuthorship W65735699A5084012950 @default.
- W65735699 hasAuthorship W65735699A5090320377 @default.
- W65735699 hasConcept C142724271 @default.
- W65735699 hasConcept C203014093 @default.
- W65735699 hasConcept C2776194053 @default.
- W65735699 hasConcept C2777077863 @default.
- W65735699 hasConcept C2777863537 @default.
- W65735699 hasConcept C2778917330 @default.
- W65735699 hasConcept C2780931953 @default.
- W65735699 hasConcept C71924100 @default.
- W65735699 hasConceptScore W65735699C142724271 @default.
- W65735699 hasConceptScore W65735699C203014093 @default.
- W65735699 hasConceptScore W65735699C2776194053 @default.
- W65735699 hasConceptScore W65735699C2777077863 @default.
- W65735699 hasConceptScore W65735699C2777863537 @default.
- W65735699 hasConceptScore W65735699C2778917330 @default.
- W65735699 hasConceptScore W65735699C2780931953 @default.
- W65735699 hasConceptScore W65735699C71924100 @default.
- W65735699 hasIssue "8" @default.
- W65735699 hasLocation W657356991 @default.
- W65735699 hasOpenAccess W65735699 @default.
- W65735699 hasPrimaryLocation W657356991 @default.
- W65735699 hasRelatedWork W1977063092 @default.
- W65735699 hasRelatedWork W2035959842 @default.
- W65735699 hasRelatedWork W2067088364 @default.
- W65735699 hasRelatedWork W2093383027 @default.
- W65735699 hasRelatedWork W2198929140 @default.
- W65735699 hasRelatedWork W2399253251 @default.
- W65735699 hasRelatedWork W2433802113 @default.
- W65735699 hasRelatedWork W65735699 @default.
- W65735699 hasRelatedWork W204144727 @default.
- W65735699 hasRelatedWork W2987778682 @default.
- W65735699 hasVolume "21" @default.
- W65735699 isParatext "false" @default.
- W65735699 isRetracted "false" @default.
- W65735699 magId "65735699" @default.
- W65735699 workType "article" @default.