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• W657417801 abstract "Recently, T2* imaging at 7Tesla (T) MRI was shown to reveal microstructural features of the cortical myeloarchitecture thanks to an increase in contrast-to-noise ratio. However, several confounds hamper the specificity of T2* measures (iron content, blood vessels, tissues orientation). Another metric, magnetization transfer ratio (MTR), is known to also be sensitive to myelin content and thus would be an excellent complementary measure because its underlying contrast mechanisms are different than that from T2*. The goal of this study was thus to combine MTR and T2* using multivariate statistics in order to gain insights into cortical myelin content. Seven healthy subjects were scanned at 7T and 3T to obtain T2* and MTR data, respectively. A multivariate myelin estimation model (MMEM) was developed, and consists in (i) normalizing T2* and MTR values and (ii) extracting their shared information using independent component analysis (ICA). B0 orientation dependence and cortical thickness were also computed and included in the model. Results showed high correlation between MTR and T2* in the whole cortex (r=0.76, p<10(-16)), suggesting that both metrics are partly driven by a common source of contrast, here assumed to be the myelin. Average MTR and T2* were respectively 31.0+/-0.3% and 32.1+/-1.4 ms. Results of the MMEM spatial distribution showed similar trends to that from histological work stained for myelin (r=0.77, p<0.01). Significant right-left differences were detected in the primary motor cortex (p<0.05), the posterior cingulate cortex (p<0.05) and the visual cortex (p<0.05). This study demonstrates that MTR and T2* are highly correlated in the cortex. The combination of MTR, T2*, CT and B0 orientation may be a useful means to study cortical myeloarchitecture with more specificity than using any of the individual methods. The MMEM framework is extendable to other contrasts such as T1 and diffusion MRI." @default.
• W657417801 created "2016-06-24" @default.
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• W657417801 date "2015-10-01" @default.
• W657417801 modified "2023-10-15" @default.
• W657417801 title "Multivariate combination of magnetization transfer, T 2 * and B0 orientation to study the myelo-architecture of the in vivo human cortex" @default.
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• W657417801 cites W1542094094 @default.
• W657417801 cites W1964570939 @default.
• W657417801 cites W1970236927 @default.
• W657417801 cites W1971082159 @default.
• W657417801 cites W1973920032 @default.
• W657417801 cites W1974388905 @default.
• W657417801 cites W1975821649 @default.
• W657417801 cites W1978325888 @default.
• W657417801 cites W1979137667 @default.
• W657417801 cites W1981155372 @default.
• W657417801 cites W1981191197 @default.
• W657417801 cites W1988366576 @default.
• W657417801 cites W1992400310 @default.
• W657417801 cites W1997453354 @default.
• W657417801 cites W1999135091 @default.
• W657417801 cites W2003365750 @default.
• W657417801 cites W2012766927 @default.
• W657417801 cites W2019775758 @default.
• W657417801 cites W2020044743 @default.
• W657417801 cites W2023904028 @default.
• W657417801 cites W2024101017 @default.
• W657417801 cites W2024205120 @default.
• W657417801 cites W2026026743 @default.
• W657417801 cites W2041046938 @default.
• W657417801 cites W2041368341 @default.
• W657417801 cites W2042564460 @default.
• W657417801 cites W2044502148 @default.
• W657417801 cites W2045419273 @default.
• W657417801 cites W2048126458 @default.
• W657417801 cites W2053887731 @default.
• W657417801 cites W2055547320 @default.
• W657417801 cites W2060182774 @default.
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• W657417801 cites W2071718644 @default.
• W657417801 cites W2072532706 @default.
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• W657417801 cites W2085764202 @default.
• W657417801 cites W2093845300 @default.
• W657417801 cites W2093864910 @default.
• W657417801 cites W2094064975 @default.
• W657417801 cites W2094232765 @default.
• W657417801 cites W2096292720 @default.
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• W657417801 doi "https://doi.org/10.1016/j.neuroimage.2015.06.033" @default.
• W657417801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4564318" @default.
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