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- W657428538 abstract "1808 Objectives The aim of the study is to assess whether misregistration (MSR) of PET-CT Cardiac data sets has a significant impact on absolute flow quantification. Methods Cardiac 82-Rb PET-CT studies of 10 patients with low pretest probability for coronary artery disease and normal myocardial perfusion imaging were analyzed. Realignment was done for the baseline rest and stress PET-CT images as necessary. Dynamic rest and stress data were obtained for myocardial blood flow (MBF) quantification using a retention model. The transmission CT and the PET emission stress images were then misregistered by 5 mm (5MSR) in the axial (left lateral direction) and coronal plane (superior direction), thereby projecting lung attenuation parameters onto the heart wall . This was repeated with a 10mm MSR (10MSR) in similar directions. Stress MBF was re-analyzed both after 5MSR and 10MSR. Sum Difference Score (SDS) was calculated using an AHA-17 segment model for all three sets of images. Results SDS at: baseline = 0; 5MSR=2.7±1.2 (p Conclusions Misregistration causes significant decrements in MFR re-emphasizing the need for routine assessment of proper registration of cardiac PET-CT datasets" @default.
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- W657428538 date "2012-05-01" @default.
- W657428538 modified "2023-09-25" @default.
- W657428538 title "Cardiac PET-CT misregistration causes significant changes in myocardial flow reserve (MFR)" @default.
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