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- W657454846 abstract "With the continued development of controlled-release technology, the need has arisen for materials with more specific drug-delivery properties. These materials include ionic or water-soluble polymers, with both hydrophilic and hydrophobic characteristics, that respond to external physical (pH, redox, heat, etc) and chemical (glucose) signals [1]. In the latter case the response is obtained with biological components, such as enzymes (e.g. glucose oxidase, GOD), that act as signal transducers in glucose-sensitive insulin releasing systems. GOD catalyzes the conversion of glucose to gluconic acid and hydrogen peroxide, liberating protons and electrons. The combination of the enzyme with a pH or redox-sensitive system gives a glucose-sensitive system. A self-regulated insulin releasing system responding to a range of glucose concentrations would have important applications. To achieve such a system many hydrogels have been studied in the past to control insulin delivery from a reservoir [2]. An elegant system, based on conformational states of polyelectrolytes grafted on porous membranes was recently developed to control water and solute permeability [3,4,5]. This system, having chemical valve function, consists of a porous membrane onto which stimuli-responsive polymers can be graft-copolymerized. The graft polymer changes shape in response to external physical stimuli. Regulation of the gating or valving function depends on the expansion and contraction of the graft chains. The enzyme GOD has been used as a sensor of glucose. Covalent bonding of GOD to the carboxyl group of polymers grafted on cellulose membranes [3] gave a glucose-sensitive membrane (Figure 1)." @default.
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- W657454846 date "1996-01-01" @default.
- W657454846 modified "2023-10-18" @default.
- W657454846 title "The Influence of Temperature on pH-Responsive Chemical Valve Systems: Thermodynamic Aspects for Drug Delivery" @default.
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- W657454846 doi "https://doi.org/10.1007/978-3-322-85017-1_48" @default.
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