FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W657634229> ?p ?o ?g. }

• W657634229 abstract "Introduction: In Africa, it is estimated that cardiovascular disease (CVD) will affect approximately 1.3 million people per annum over the following 20 years. C-reactive protein (CRP) is a predictor of CVD risk and certain CRP gene polymorphisms can result in altered CRP concentrations. The distribution of CRP gene polymorphisms is ethnic-specific and extrapolating information from other populations to the black South African population, reported to harbour considerable genetic variation, should be avoided. This highlights the fact that genetic research among black South Africans is necessary. Objectives: The main aim of this dissertation was to determine the association between various polymorphisms (reported and novel [single nucleotide polymorphisms (SNPs)] within the CRP gene with CRP concentrations [measured as high sensitivity (hs)-CRP concentrations] in a black South African population undergoing an epidemiological transition. Interactions between specific CRP polymorphisms and certain environmental factors on hs-CRP concentrations were also investigated. Methods: This cross-sectional study (n=1,588) was nested within the Prospective Urban and Rural Epidemiological (PURE) study. Genotyping was performed using Illumina VeraCode technology on the BeadXpress platform. Hs-CRP concentrations were measured by the use of a sequential multiple analyser computer (SMAC) through a particle-enhanced immunoturbidometric assay. Results: All the SNPs adhered to the assumptions of Hardy-Weinberg equilibrium, although the distribution of several SNPs differed from that reported in other population groups. Three SNPs (rs3093058, rs3093062 and rs3093068) were associated with a significant (p ≤ 0.05) increase in CRP concentrations. Five SNPs (rs1205, rs1341665, rs2794520, rs7553007 and rs2027471) were associated with a significant (p ≤ 0.05) decrease in CRP concentrations. This difference in effect was most probably due to changes in gene function brought about by the localisation of these SNPs in the CRP gene. Men and urban individuals were more likely to present with significant associations between the SNPs investigated and CRP concentrations. The difference in the prevalence of the alleles associated with higher CRP concentrations in this population compared to non-African populations could possibly explain the increased CRP concentrations that are observed in the black South African population. Gene-gender (rs1205, rs1341665 and rs2027474) as well as gene-environmental (rs3093068) interactions were also observed. Conclusions: CRP concentrations are in themselves a complex trait and there are many factors at play that influence their expression. Numerous factors (both genetic and environmental) are involved and no single factor acting alone is likely to have enough of an influence to be used as a clinical diagnostic test of CRP concentrations. These results provide valuable information on the regulation of CRP in a black South African population as well as contribute to the literature of CRP on a global level." @default.
• W657634229 created "2016-06-24" @default.
• W657634229 creator A5013465982 @default.
• W657634229 date "2013-01-01" @default.
• W657634229 modified "2023-09-27" @default.
• W657634229 title "The relevance of specific c–reactive protein genetic variants towards cardiovascular disease risk in a black South African population undergoing an epidemiological transition" @default.
• W657634229 cites W103271583 @default.
• W657634229 cites W104618638 @default.
• W657634229 cites W110619209 @default.
• W657634229 cites W1483247593 @default.
• W657634229 cites W1507921386 @default.
• W657634229 cites W1512972301 @default.
• W657634229 cites W1514079210 @default.
• W657634229 cites W1528748012 @default.
• W657634229 cites W1570456520 @default.
• W657634229 cites W1579192215 @default.
• W657634229 cites W1583327662 @default.
• W657634229 cites W1604621894 @default.
• W657634229 cites W1651383390 @default.
• W657634229 cites W1774830833 @default.
• W657634229 cites W1836112660 @default.
• W657634229 cites W1874706679 @default.
• W657634229 cites W1910361842 @default.
• W657634229 cites W1912411284 @default.
• W657634229 cites W1921894845 @default.
• W657634229 cites W1946263363 @default.
• W657634229 cites W1950462993 @default.
• W657634229 cites W1953389641 @default.
• W657634229 cites W1964336741 @default.
• W657634229 cites W1967832563 @default.
• W657634229 cites W1970643505 @default.
• W657634229 cites W1972696558 @default.
• W657634229 cites W1975396627 @default.
• W657634229 cites W1975546604 @default.
• W657634229 cites W1976077702 @default.
• W657634229 cites W1981237781 @default.
• W657634229 cites W1982969737 @default.
• W657634229 cites W1985953874 @default.
• W657634229 cites W1992413243 @default.
• W657634229 cites W1992486326 @default.
• W657634229 cites W1992814825 @default.
• W657634229 cites W1993060519 @default.
• W657634229 cites W1996810010 @default.
• W657634229 cites W2000797253 @default.
• W657634229 cites W2001587667 @default.
• W657634229 cites W2002329154 @default.
• W657634229 cites W2002833891 @default.
• W657634229 cites W2006353464 @default.
• W657634229 cites W2007272726 @default.
• W657634229 cites W2009171533 @default.
• W657634229 cites W2015071873 @default.
• W657634229 cites W2015158463 @default.
• W657634229 cites W2017917042 @default.
• W657634229 cites W2018026125 @default.
• W657634229 cites W2019610812 @default.
• W657634229 cites W2025782661 @default.
• W657634229 cites W2029965213 @default.
• W657634229 cites W2031899050 @default.
• W657634229 cites W2032019813 @default.
• W657634229 cites W2032485049 @default.
• W657634229 cites W2032634579 @default.
• W657634229 cites W2032826669 @default.
• W657634229 cites W2032991830 @default.
• W657634229 cites W2039420330 @default.
• W657634229 cites W2042346989 @default.
• W657634229 cites W2043610326 @default.
• W657634229 cites W2044036686 @default.
• W657634229 cites W2046117118 @default.
• W657634229 cites W2052353914 @default.
• W657634229 cites W2056031168 @default.
• W657634229 cites W2056539295 @default.
• W657634229 cites W2058709767 @default.
• W657634229 cites W2058939989 @default.
• W657634229 cites W2059279349 @default.
• W657634229 cites W2059335306 @default.
• W657634229 cites W2059628966 @default.
• W657634229 cites W2060371381 @default.
• W657634229 cites W2061511405 @default.
• W657634229 cites W2061926910 @default.
• W657634229 cites W2063170999 @default.
• W657634229 cites W2063572291 @default.
• W657634229 cites W2064023438 @default.
• W657634229 cites W2068041274 @default.
• W657634229 cites W2069749827 @default.
• W657634229 cites W2070009842 @default.
• W657634229 cites W2071875912 @default.
• W657634229 cites W2072005929 @default.
• W657634229 cites W2072397216 @default.
• W657634229 cites W2075924129 @default.
• W657634229 cites W2076633296 @default.
• W657634229 cites W2076883571 @default.
• W657634229 cites W2078921008 @default.
• W657634229 cites W2079011636 @default.
• W657634229 cites W2079168568 @default.
• W657634229 cites W2079306327 @default.
• W657634229 cites W2079522334 @default.
• W657634229 cites W2080423600 @default.
• W657634229 cites W2083683919 @default.
• W657634229 cites W2085558085 @default.
• W657634229 cites W2085943260 @default.

• next