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Matches in SemOpenAlex for { <https://semopenalex.org/work/W658308441> ?p ?o ?g. }

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• W658308441 abstract "The development of MEK inhibitors has led to improved progression-free survival in patients with mutant BRAF(V600) cancers when used in combination with BRAF inhibitors. However, resistance to combination therapy remains an issue. This review summarizes our current understanding of the role of MEK in cancer cell proliferation and the mechanisms which lead to resistance in patients. Specific adverse events, which have been linked to the MEK inhibitor class, have been described. Future combinations of MEK inhibitors with other cancer therapy options, currently under investigation in clinical trials, are also discussed." @default.
• W658308441 created "2016-06-24" @default.
• W658308441 creator A5003435415 @default.
• W658308441 creator A5022619396 @default.
• W658308441 date "2015-08-01" @default.
• W658308441 modified "2023-10-16" @default.
• W658308441 title "MEK inhibitors beyond monotherapy: current and future development" @default.
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• W658308441 doi "https://doi.org/10.1016/j.coph.2015.05.012" @default.
• W658308441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26057212" @default.
• W658308441 hasPublicationYear "2015" @default.
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