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• W658386604 abstract "The studies described in this thesis aimed to identify novel factors involved in the regulation of longitudinal growth and bone mineralization in response to growth hormone (GH) treatment. This was done by performing a single factor study (Paper I) where it was found that growth response was negatively correlated with adiponectin levels during the first year of GH treatment in short prepubertal children. Thereafter a genomic approach using microarray was used to identify GH and insulin-like growth factor I responsive genes in primary cultured human chondrocytes, from the growth plate, where GH has direct and indirect effects (Paper II). The COMP gene was found to be up-regulated by GH, which was confirmed using ELISA in short prepubertal children. In Papers III–V a pharmacoproteomic approach was used to identify novel GHregulated protein markers for longitudinal growth and bone mineralization. Serum protein expression profiles during the first year of GH treatment were analysed using SELDI-TOF in two different study groups. In Paper III changes in protein peak intensities allowed 82% of children to be correctly classified as good or poor responders. In Paper IV and V it was found that it was possible to predict the 2-year growth response and bone mineralization and by comparing the proteins in the regression models it was found that these are partly dissociated mechanisms. The proteins identified in Paper III-V were Apolipoprotein (Apo) A-I, Apo A-II, Apo C-I, Apo C-III, transthyretin, serum amyloid A4 and haemoglobin beta. All proteins except haemoglobin beta were related to the high-density lipoprotein. Robust statistical methods were used and developed to ensure valid proteomic data as well as reliable results. In conclusion: different techniques from ELISAs to genomics and proteomics were used to identify novel GH-dependent factors. Our results suggest that nutritional factors may have a role in determining GH responsiveness. In future, this knowledge could be useful in the development of tools for the diagnosis and individualized treatment of short children, independently of low GH secretion or low GH sensitivity." @default.
• W658386604 created "2016-06-24" @default.
• W658386604 creator A5058872928 @default.
• W658386604 date "2009-11-27" @default.
• W658386604 modified "2023-09-27" @default.
• W658386604 title "Identification of novel growth hormone-regulated factors" @default.
• W658386604 cites W1492391409 @default.
• W658386604 cites W1500679020 @default.
• W658386604 cites W1533580110 @default.
• W658386604 cites W153541530 @default.
• W658386604 cites W1558777374 @default.
• W658386604 cites W1570155932 @default.
• W658386604 cites W1585195212 @default.
• W658386604 cites W1771833573 @default.
• W658386604 cites W188151426 @default.
• W658386604 cites W1888987284 @default.
• W658386604 cites W1901498384 @default.
• W658386604 cites W1960896611 @default.
• W658386604 cites W1963558983 @default.
• W658386604 cites W1963690512 @default.
• W658386604 cites W1964139322 @default.
• W658386604 cites W1964485007 @default.
• W658386604 cites W1964814161 @default.
• W658386604 cites W1965915581 @default.
• W658386604 cites W1966459931 @default.
• W658386604 cites W1966593149 @default.
• W658386604 cites W1967753130 @default.
• W658386604 cites W1967931968 @default.
• W658386604 cites W1969480757 @default.
• W658386604 cites W1970156673 @default.
• W658386604 cites W1970575316 @default.
• W658386604 cites W1971185974 @default.
• W658386604 cites W1971345463 @default.
• W658386604 cites W1972763246 @default.
• W658386604 cites W1978141264 @default.
• W658386604 cites W1978511186 @default.
• W658386604 cites W1980530794 @default.
• W658386604 cites W1981296559 @default.
• W658386604 cites W1981855172 @default.
• W658386604 cites W1984191109 @default.
• W658386604 cites W1984211946 @default.
• W658386604 cites W1986236166 @default.
• W658386604 cites W1986875004 @default.
• W658386604 cites W1987447544 @default.
• W658386604 cites W1988999184 @default.
• W658386604 cites W1989140409 @default.
• W658386604 cites W1991366673 @default.
• W658386604 cites W1994784206 @default.
• W658386604 cites W1996235842 @default.
• W658386604 cites W1996460442 @default.
• W658386604 cites W1996611996 @default.
• W658386604 cites W1996667314 @default.
• W658386604 cites W1996713062 @default.
• W658386604 cites W2004365533 @default.
• W658386604 cites W2004706898 @default.
• W658386604 cites W2005259839 @default.
• W658386604 cites W2005388253 @default.
• W658386604 cites W2006705416 @default.
• W658386604 cites W2007477730 @default.
• W658386604 cites W2010374889 @default.
• W658386604 cites W2010611103 @default.
• W658386604 cites W2012715520 @default.
• W658386604 cites W2013014315 @default.
• W658386604 cites W2013715040 @default.
• W658386604 cites W2013835332 @default.
• W658386604 cites W2016291122 @default.
• W658386604 cites W2016508574 @default.
• W658386604 cites W2016986133 @default.
• W658386604 cites W2017415179 @default.
• W658386604 cites W2017447829 @default.
• W658386604 cites W2018009677 @default.
• W658386604 cites W2018045653 @default.
• W658386604 cites W2018840890 @default.
• W658386604 cites W2021838776 @default.
• W658386604 cites W2021914226 @default.
• W658386604 cites W2024394264 @default.
• W658386604 cites W2025974332 @default.
• W658386604 cites W2026230914 @default.
• W658386604 cites W2026436880 @default.
• W658386604 cites W2026471944 @default.
• W658386604 cites W2026787913 @default.
• W658386604 cites W2027340926 @default.
• W658386604 cites W2027904175 @default.
• W658386604 cites W2028398835 @default.
• W658386604 cites W2031808976 @default.
• W658386604 cites W2034446662 @default.
• W658386604 cites W2034960978 @default.
• W658386604 cites W2035608590 @default.
• W658386604 cites W2036289431 @default.
• W658386604 cites W2038619963 @default.
• W658386604 cites W2039660011 @default.
• W658386604 cites W2039776032 @default.
• W658386604 cites W2040155058 @default.
• W658386604 cites W2042652903 @default.
• W658386604 cites W2042932723 @default.
• W658386604 cites W2044472451 @default.
• W658386604 cites W2047089089 @default.
• W658386604 cites W2047102142 @default.
• W658386604 cites W2048642192 @default.
• W658386604 cites W2048667936 @default.

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