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- W65840119 abstract "Brain metastases are a common cause of morbidity and mortality in patients with non-small cell lung cancer (NSCLC). Though the prognosis for NSCLC patients with brain metastases is generally quite poor, select patients may achieve prolonged survival with aggressive surgical resection or stereotactic radiosurgery combined with whole brain radiotherapy (WBRT) for brain metastases. In recent years, several single-institutional studies have reported long-term survival outcomes in NSCLC patients with a limited number of synchronous brain metastases using aggressive local approaches to both the intracranial and primary thoracic disease, yet the optimal treatment and selection of those patients who might benefit is not well defined. Treatment options for NSCLC patients with oligometastatic synchronous brain metastases, including radical local approaches to brain metastases and primary thoracic disease will be discussed in this review. A management algorithm based on the available evidence regarding management options and prognostic factors for NSCLC patients with synchronous brain metastases is proposed. Randomized clinical trials are needed to define further the role of radiotherapy in this patient population and current clinical trials are reviewed." @default.
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- W65840119 date "2014-01-01" @default.
- W65840119 modified "2023-10-16" @default.
- W65840119 title "Radiation Management of Synchronous Brain Metastases from Non-Small Cell Lung Cancer" @default.
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- W65840119 doi "https://doi.org/10.1016/b978-0-12-800896-6.00017-6" @default.
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