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• W65842783 abstract "In the ensuing discussion attention will be given to acute adverse effects of those agents which are used for the induction of general anaesthesia by the intravenous (i. v.) route. The term “hypersensitivity reactions” is used in preference to “allergic reactions”, contrary to the need for more precise definitions. With certain intravenous anaesthetics, e. g. thiopentone, such reactions are nearly always due to allergy but with other i. v. induction agents such as steroid anaesthetics and eugenols only a proportion (around 50% with both groups) of the reactions appear to be allergic in nature, the remainder being due to direct histamine release or some other mechanism not involving a specific immune response to the drug. It is often impossible to distinguish between truly allergic reactions and reactions of the latter type, particularly between true anaphylaxis (mediated by anaphylactic, drug-specific antibodies) and anaphylactoid reactions, where chemical mediators such as histamine are released as a result of a different abnormality (idiosyncrasy).KeywordsLocal AnaestheticHistamine ReleaseAnaphylactoid ReactionIntravenous AnaestheticLocal AnaestheticsThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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• W65842783 creator A5063839160 @default.
• W65842783 date "1983-01-01" @default.
• W65842783 modified "2023-10-14" @default.
• W65842783 title "General and Local Anaesthetics" @default.
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• W65842783 doi "https://doi.org/10.1007/978-3-642-69088-4_10" @default.
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