FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W65867874> ?p ?o ?g. }

• W65867874 endingPage "249" @default.
• W65867874 startingPage "237" @default.
• W65867874 abstract "IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of responsive genes. IFNs were the first human proteins to be effective in cancer therapy and were among the first recombinant DNA products to be used clinically. Both quality and quantity of life has been improved in response to IFNs in various malignancies. Despite its beneficial effects, unraveling the mechanisms of the anti-tumor effects of IFN has proven to be a complex task. IFNs may mediate anti-tumor effects either indirectly by modulating immunomodulatory and anti-angiogenic responses or by directly affecting proliferation or cellular differentiation of tumor cells. Both direct or indirect effects of IFNs result from induction of a subset of genes, called IFN stimulated genes (ISGs). In addition to the ISGs implicated in anti-viral, anti-angiogenic, immunomodulatory and cell cycle inhibitory effects, oligonucleotide microarray studies have identified ISGs with apoptotic functions. These include TNF-α related apoptosis inducing ligand (TRAIL/Apo2L), Fas/FasL, XIAP associated factor-1 (XAF-1), caspase-4, caspase-8, dsRNA activated protein kinase (PKR), 2'5'A oligoadenylate synthetase (OAS), death activating protein kinases (DAP kinase), phospholipid scramblase, galectin 9, IFN regulatory factors (IRFs), promyelocytic leukemia gene (PML) and regulators of IFN induced death (RIDs). In vitro IFN-α, IFN-β and IFN-γ induced apoptosis in multiple cell lines of varied histologies. This review will emphasize possible mechanisms and the role of ISGs involved in mediating apoptotic function of IFNs." @default.
• W65867874 created "2016-06-24" @default.
• W65867874 creator A5011842741 @default.
• W65867874 creator A5056562780 @default.
• W65867874 creator A5065048691 @default.
• W65867874 creator A5067358586 @default.
• W65867874 creator A5081150848 @default.
• W65867874 creator A5084601919 @default.
• W65867874 creator A5087309137 @default.
• W65867874 date "2003-01-01" @default.
• W65867874 modified "2023-10-16" @default.
• W65867874 cites W145168120 @default.
• W65867874 cites W1479906884 @default.
• W65867874 cites W1490480018 @default.
• W65867874 cites W1491325575 @default.
• W65867874 cites W1504057655 @default.
• W65867874 cites W1557686543 @default.
• W65867874 cites W1563458559 @default.
• W65867874 cites W1633525445 @default.
• W65867874 cites W1638465953 @default.
• W65867874 cites W1768008898 @default.
• W65867874 cites W1798713465 @default.
• W65867874 cites W1966677529 @default.
• W65867874 cites W1967912613 @default.
• W65867874 cites W1968694633 @default.
• W65867874 cites W1969962178 @default.
• W65867874 cites W1970100286 @default.
• W65867874 cites W1970677867 @default.
• W65867874 cites W1973479681 @default.
• W65867874 cites W1980041786 @default.
• W65867874 cites W1980169152 @default.
• W65867874 cites W1980635119 @default.
• W65867874 cites W1982658621 @default.
• W65867874 cites W1987811570 @default.
• W65867874 cites W1989380851 @default.
• W65867874 cites W1994543822 @default.
• W65867874 cites W2001842265 @default.
• W65867874 cites W2018426264 @default.
• W65867874 cites W2025128734 @default.
• W65867874 cites W2026287156 @default.
• W65867874 cites W2028850807 @default.
• W65867874 cites W2029275361 @default.
• W65867874 cites W2029765186 @default.
• W65867874 cites W2029782698 @default.
• W65867874 cites W2030552125 @default.
• W65867874 cites W2033417996 @default.
• W65867874 cites W2035882918 @default.
• W65867874 cites W2036853011 @default.
• W65867874 cites W2041204061 @default.
• W65867874 cites W2047391267 @default.
• W65867874 cites W2047509412 @default.
• W65867874 cites W2048263113 @default.
• W65867874 cites W2053827853 @default.
• W65867874 cites W2054164997 @default.
• W65867874 cites W2056043388 @default.
• W65867874 cites W2056217426 @default.
• W65867874 cites W2056501152 @default.
• W65867874 cites W2060204096 @default.
• W65867874 cites W2061497413 @default.
• W65867874 cites W2061517203 @default.
• W65867874 cites W2064393764 @default.
• W65867874 cites W2068025988 @default.
• W65867874 cites W2069514830 @default.
• W65867874 cites W2071085094 @default.
• W65867874 cites W2072304361 @default.
• W65867874 cites W2075413744 @default.
• W65867874 cites W2075616620 @default.
• W65867874 cites W2077671923 @default.
• W65867874 cites W2080419891 @default.
• W65867874 cites W2081628690 @default.
• W65867874 cites W2083794542 @default.
• W65867874 cites W2085546686 @default.
• W65867874 cites W2085669605 @default.
• W65867874 cites W2087004183 @default.
• W65867874 cites W2088506877 @default.
• W65867874 cites W2093238198 @default.
• W65867874 cites W2094985040 @default.
• W65867874 cites W2098776512 @default.
• W65867874 cites W2101028231 @default.
• W65867874 cites W2101083359 @default.
• W65867874 cites W2103565638 @default.
• W65867874 cites W2104773672 @default.
• W65867874 cites W2108527315 @default.
• W65867874 cites W2109283126 @default.
• W65867874 cites W2109510813 @default.
• W65867874 cites W2110044798 @default.
• W65867874 cites W2113180936 @default.
• W65867874 cites W2115970169 @default.
• W65867874 cites W2118331214 @default.
• W65867874 cites W2119847512 @default.
• W65867874 cites W2122994357 @default.
• W65867874 cites W2123239648 @default.
• W65867874 cites W2123986453 @default.
• W65867874 cites W2128575466 @default.
• W65867874 cites W2130988210 @default.
• W65867874 cites W2140442649 @default.
• W65867874 cites W2145356695 @default.
• W65867874 cites W2149444093 @default.

• next