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• W6587459 abstract "Extracellular Matrix Alterations in Patients With Paroxysmal and Persistent Atrial Fibrillation: Biochemical Assessment of Collagen Type-I Turnover Eleftherios M. Kallergis, Emmanuel G. Manios, Emmanuel M. Kanoupakis, Hercules E. Mavrakis, Dimitris A. Arfanakis, Niki E. Maliaraki, Chrisovalantis E. Lathourakis, Gregory I. Chlouverakis, Panos E. Vardas Serum markers of collagen type-I turnover differed significantly both between patients with atrial fibrillation (AF) and sinus rhythm and between paroxysmal and persistent AF patients, suggesting that the intensity of the extracellular synthesis and degradation of collagen type-I may be related to the burden or type of AF. Although cardiac biopsy is the gold standard for documenting and monitoring myocardial fibrosis, the development of noninvasive methods to indicate the presence of myocardial fibrosis in AF and in other clinical conditions is particularly attractive and could have a broader application. We investigated whether the serum markers of collagen turnover differed in various forms of atrial fibrillation (AF) and in sinus rhythm (SR) in humans. Structural alterations and fibrosis have been implicated in the generation and perpetuation of AF. Serum C-terminal propeptide of collagen type-I (CICP), C-terminal telopeptide of collagen type-I (CITP), matrix metalloproteinase-1, and tissue inhibitor of matrix metalloproteinases-1 were measured as markers of collagen synthesis and degradation in 70 patients with AF and 20 healthy control subjects in SR. C-terminal propeptide of collagen type-I and CITP were significantly higher in AF patients than in control subjects (91 ± 27 ng/ml vs. 67 ± 11 ng/ml, p < 0.001 and 0.38 ± 0.20 ng/ml vs. 0.25 ± 0.08 ng/ml, p < 0.001, respectively). Persistent AF patients had higher levels of CICP (105 ± 28 ng/ml vs. 80 ± 21 ng/ml, p < 0.001), but not CITP, compared with those with paroxysmal AF. Patients with persistent AF had lower levels of matrix metalloproteinase-1 but increased levels of tissue inhibitor of matrix metalloproteinases-1 compared with patients with paroxysmal AF (11.90 ± 4.79 ng/ml vs. 14.98 ± 6.28 ng/ml, p = 0.03 and 155 ± 45 ng/ml vs. 130 ± 38 ng/ml, p < 0.001, respectively). Tissue inhibitor of matrix metalloproteinases-1 levels were significantly lower in control subjects compared with those in both paroxysmal and persistent AF patients (102 ± 15 ng/ml vs. 130 ± 38 ng/ml vs. 155 ± 45 ng/ml, respectively, p < 0.001). Serum markers of collagen type-I turnover differed significantly between patients with AF and SR. Furthermore, these markers also differed significantly between paroxysmal and persistent AF patients, suggesting that the intensity of the extracellular synthesis and degradation of collagen type-I may be related to the burden or type of AF." @default.
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• W6587459 date "2008-07-01" @default.
• W6587459 modified "2023-09-26" @default.
• W6587459 title "Extracellular Matrix Alterations in Patients With Paroxysmal and Persistent Atrial Fibrillation" @default.
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• W6587459 doi "https://doi.org/10.1016/j.jacc.2008.03.045" @default.
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