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- W65915295 abstract "Lateral inhibition is a circuit motif found throughout the nervous system that often generates contrast enhancement and center-surround receptive fields. While widespread lateral inhibition of mitral cells (the principal output neurons of the bulb) is mediated by granule cells (inhibitory interneurons), due to the distributed representation of odorant-evoked activity it is currently unclear how this inhibition is specified or what functions it mediates. Given the reciprocal nature of the connection between mitral and granule cells, mitral cells that are the targets of lateral inhibition (postsynaptic) are able to modulate the activity of the granule cells mediating this lateral inhibition. This led us to hypothesize that lateral inhibition could be modulated by the activity of both pre- as well as postsynaptic mitral cells. I first characterize the lateral interactions between mitral cells and show that the effectiveness of lateral inhibition between them is dependent on the activity of the postsynaptic neuron such that lateral inhibition is only able to reduce the firing rate within a specific range of postsynaptic firing rates. I call this activity-dependent lateral inhibition. I then investigated this novel form of inhibition further and provide evidence indicating that it results from cooperative activation of the inhibitory granule cells.I investigated the mechanism and functional implications of these physiological results further using computational techniques. First, I show that integration of activity between pre- and postsynaptic mitral cells within a granule cell is sufficient to result in activity-dependent inhibition. I then used this model to show that activity-dependent inhibition is able to enhance the contrast and decorrelate initially similar input patterns to the network in a spatially independent manner. These results provide evidence for a novel form of neuronal interaction dependent on the activity of neurons within the network which could have important functional implications in olfaction as well as other brain areas." @default.
- W65915295 created "2016-06-24" @default.
- W65915295 creator A5048987602 @default.
- W65915295 date "2008-10-29" @default.
- W65915295 modified "2023-09-23" @default.
- W65915295 title "Activity-dependent lateral inhibition in the mouse olfactory bulb" @default.
- W65915295 cites W1243663029 @default.
- W65915295 cites W133776480 @default.
- W65915295 cites W1479720172 @default.
- W65915295 cites W1484628435 @default.
- W65915295 cites W1485458577 @default.
- W65915295 cites W1488083617 @default.
- W65915295 cites W1493250243 @default.
- W65915295 cites W1494241005 @default.
- W65915295 cites W1501360999 @default.
- W65915295 cites W1503588279 @default.
- W65915295 cites W1503602982 @default.
- W65915295 cites W1513132249 @default.
- W65915295 cites W1518313412 @default.
- W65915295 cites W1528612804 @default.
- W65915295 cites W1528771346 @default.
- W65915295 cites W1529082476 @default.
- W65915295 cites W1532842753 @default.
- W65915295 cites W1533559637 @default.
- W65915295 cites W1535200077 @default.
- W65915295 cites W1538688709 @default.
- W65915295 cites W1554372348 @default.
- W65915295 cites W1555762208 @default.
- W65915295 cites W1568903867 @default.
- W65915295 cites W1580513152 @default.
- W65915295 cites W1587342226 @default.
- W65915295 cites W1590824729 @default.
- W65915295 cites W1598291226 @default.
- W65915295 cites W1603253070 @default.
- W65915295 cites W1603858169 @default.
- W65915295 cites W1604055304 @default.
- W65915295 cites W1605797652 @default.
- W65915295 cites W1626920804 @default.
- W65915295 cites W1628580856 @default.
- W65915295 cites W1635997158 @default.
- W65915295 cites W1664434196 @default.
- W65915295 cites W1674744817 @default.
- W65915295 cites W1678355425 @default.
- W65915295 cites W1712796578 @default.
- W65915295 cites W173349528 @default.
- W65915295 cites W1740677000 @default.
- W65915295 cites W1757333299 @default.
- W65915295 cites W1763296052 @default.
- W65915295 cites W1767080440 @default.
- W65915295 cites W1798558936 @default.
- W65915295 cites W1808569803 @default.
- W65915295 cites W1818082897 @default.
- W65915295 cites W1821468701 @default.
- W65915295 cites W1843850136 @default.
- W65915295 cites W1870748759 @default.
- W65915295 cites W1898031307 @default.
- W65915295 cites W1923589122 @default.
- W65915295 cites W1946530150 @default.
- W65915295 cites W1961943243 @default.
- W65915295 cites W1963026571 @default.
- W65915295 cites W1963807489 @default.
- W65915295 cites W1964440976 @default.
- W65915295 cites W1964914451 @default.
- W65915295 cites W1965370880 @default.
- W65915295 cites W1965377078 @default.
- W65915295 cites W1965953864 @default.
- W65915295 cites W1966063464 @default.
- W65915295 cites W1969319931 @default.
- W65915295 cites W1969954889 @default.
- W65915295 cites W1971590664 @default.
- W65915295 cites W1972400286 @default.
- W65915295 cites W1972994374 @default.
- W65915295 cites W1973230208 @default.
- W65915295 cites W1973426426 @default.
- W65915295 cites W1973659883 @default.
- W65915295 cites W1975156107 @default.
- W65915295 cites W1975302642 @default.
- W65915295 cites W1977110625 @default.
- W65915295 cites W1977576332 @default.
- W65915295 cites W1978456045 @default.
- W65915295 cites W1980721898 @default.
- W65915295 cites W1982602809 @default.
- W65915295 cites W1983022541 @default.
- W65915295 cites W1983523615 @default.
- W65915295 cites W1983544170 @default.
- W65915295 cites W1984508253 @default.
- W65915295 cites W1985363221 @default.
- W65915295 cites W1987211298 @default.
- W65915295 cites W1988813033 @default.
- W65915295 cites W1992219804 @default.
- W65915295 cites W1992646289 @default.
- W65915295 cites W1992994620 @default.
- W65915295 cites W1993008927 @default.
- W65915295 cites W1994572841 @default.
- W65915295 cites W1995249992 @default.
- W65915295 cites W1997568797 @default.
- W65915295 cites W2001688314 @default.
- W65915295 cites W2002338497 @default.
- W65915295 cites W2002577038 @default.
- W65915295 cites W2002861536 @default.