FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W659156007> ?p ?o ?g. }

• W659156007 endingPage "43" @default.
• W659156007 startingPage "36" @default.
• W659156007 abstract "Betaine plays important roles that include acting as a methyl donor and converting homocysteine (Hcy) to methionine. Elevated plasma Hcy levels are known as hyperhomocysteinemia (HHcy) and contribute to impairments of learning and memory. Although it is commonly known that betaine plays an important role in Hcy metabolism, the effects of betaine on Hcy-induced memory impairment have not been investigated. Previously, we demonstrated the beneficial effects of betaine on acute stress and lipopolysaccharide-induced memory impairment. In the present study, we investigated whether betaine ameliorates Hcy-induced memory impairment and the underlying mechanisms of this putative effect. Mice were treated with Hcy (0.162mg/kg, s.c.) twice a day for nine days, and betaine (25mg/kg, s.c.) was administered 30min before the Hcy injections. The memory functions were evaluated using a spontaneous alternation performance test (Y-maze) at seven days and a step-down type passive avoidance test (SD) at nine and ten days after Hcy injection. We found that betaine suppressed the memory impairment induced by repeated Hcy injections. However, the blood concentrations of Hcy were significantly increased in the Hcy-treated mice immediately after the passive avoidance test, and betaine did not prevent this increase. Furthermore, Hcy induces redox stress in part by activating matrix metalloproteinase-9 (MMP-9), which leads to BBB dysfunction. Therefore, we tested whether betaine affected MMP-9 activity. Interestingly, treatment with betaine significantly inhibited Hcy-induced MMP-9 activity in the frontal cortex but not in the hippocampus after acute Hcy injection. These results suggest that the changes in MMP-9 activity after betaine treatment might have been partially responsible for the amelioration of the memory deficits and that MMP-9 might be a candidate therapeutic target for HHcy." @default.
• W659156007 created "2016-06-24" @default.
• W659156007 creator A5010845492 @default.
• W659156007 creator A5015363804 @default.
• W659156007 creator A5022082357 @default.
• W659156007 creator A5037598159 @default.
• W659156007 creator A5077039517 @default.
• W659156007 creator A5088920500 @default.
• W659156007 date "2015-10-01" @default.
• W659156007 modified "2023-09-27" @default.
• W659156007 title "Betaine prevents homocysteine-induced memory impairment via matrix metalloproteinase-9 in the frontal cortex" @default.
• W659156007 cites W1499693439 @default.
• W659156007 cites W1588584323 @default.
• W659156007 cites W1828744404 @default.
• W659156007 cites W1962867466 @default.
• W659156007 cites W1969713114 @default.
• W659156007 cites W1973238910 @default.
• W659156007 cites W1975211811 @default.
• W659156007 cites W1982802870 @default.
• W659156007 cites W1986443156 @default.
• W659156007 cites W1992981081 @default.
• W659156007 cites W1994533278 @default.
• W659156007 cites W1998476386 @default.
• W659156007 cites W1999957169 @default.
• W659156007 cites W2004030788 @default.
• W659156007 cites W2016541635 @default.
• W659156007 cites W2017429999 @default.
• W659156007 cites W2018917291 @default.
• W659156007 cites W2020415425 @default.
• W659156007 cites W2021494027 @default.
• W659156007 cites W2027665192 @default.
• W659156007 cites W2038630817 @default.
• W659156007 cites W2039778156 @default.
• W659156007 cites W2051123699 @default.
• W659156007 cites W2055159861 @default.
• W659156007 cites W2057576750 @default.
• W659156007 cites W2058288565 @default.
• W659156007 cites W2059207866 @default.
• W659156007 cites W2065705239 @default.
• W659156007 cites W2068015531 @default.
• W659156007 cites W2070940233 @default.
• W659156007 cites W2072840073 @default.
• W659156007 cites W2077279137 @default.
• W659156007 cites W2080053658 @default.
• W659156007 cites W2085154880 @default.
• W659156007 cites W2085886216 @default.
• W659156007 cites W2085971550 @default.
• W659156007 cites W2091855875 @default.
• W659156007 cites W2097510913 @default.
• W659156007 cites W2109992973 @default.
• W659156007 cites W2113892795 @default.
• W659156007 cites W2123657382 @default.
• W659156007 cites W2125712619 @default.
• W659156007 cites W2126230337 @default.
• W659156007 cites W2140723805 @default.
• W659156007 cites W2141502079 @default.
• W659156007 cites W2142066097 @default.
• W659156007 cites W2143409915 @default.
• W659156007 cites W2148516422 @default.
• W659156007 cites W2152365231 @default.
• W659156007 cites W2155614484 @default.
• W659156007 cites W2156635660 @default.
• W659156007 cites W2159058075 @default.
• W659156007 cites W2159397285 @default.
• W659156007 cites W2165360441 @default.
• W659156007 cites W2166148002 @default.
• W659156007 cites W2166781237 @default.
• W659156007 cites W2337301504 @default.
• W659156007 doi "https://doi.org/10.1016/j.bbr.2015.06.004" @default.
• W659156007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26057356" @default.
• W659156007 hasPublicationYear "2015" @default.
• W659156007 type Work @default.
• W659156007 sameAs 659156007 @default.
• W659156007 citedByCount "19" @default.
• W659156007 countsByYear W6591560072016 @default.
• W659156007 countsByYear W6591560072017 @default.
• W659156007 countsByYear W6591560072018 @default.
• W659156007 countsByYear W6591560072019 @default.
• W659156007 countsByYear W6591560072020 @default.
• W659156007 countsByYear W6591560072021 @default.
• W659156007 countsByYear W6591560072022 @default.
• W659156007 crossrefType "journal-article" @default.
• W659156007 hasAuthorship W659156007A5010845492 @default.
• W659156007 hasAuthorship W659156007A5015363804 @default.
• W659156007 hasAuthorship W659156007A5022082357 @default.
• W659156007 hasAuthorship W659156007A5037598159 @default.
• W659156007 hasAuthorship W659156007A5077039517 @default.
• W659156007 hasAuthorship W659156007A5088920500 @default.
• W659156007 hasConcept C126322002 @default.
• W659156007 hasConcept C134018914 @default.
• W659156007 hasConcept C15744967 @default.
• W659156007 hasConcept C169760540 @default.
• W659156007 hasConcept C169900460 @default.
• W659156007 hasConcept C185592680 @default.
• W659156007 hasConcept C2776523773 @default.
• W659156007 hasConcept C2777090595 @default.
• W659156007 hasConcept C2777248517 @default.
• W659156007 hasConcept C2780912031 @default.

• next