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- W659353547 abstract "The Dark brown (DB) mutation in chickens reduces expression of black eumelanin and enhances expression of red pheomelanin, but only in certain parts of the plumage. Here, we present genetic evidence that an 8.3-kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the DB phenotype. The SOX10 transcription factor has a well-established role in melanocyte biology and is essential for melanocyte migration and survival. Previous studies have demonstrated that the mouse homolog of a highly conserved element within the deleted region is a SOX10 enhancer. The mechanism of action of this mutation remains to be established, but one possible scenario is that the deletion leads to reduced SOX10 expression which in turn down-regulates expression of key enzymes in pigment synthesis such as tyrosinase. Lower tyrosinase activity leads to a shift toward a more pheomelanistic (reddish) plumage color, which is the characteristic feature of the DB phenotype." @default.
- W659353547 created "2016-06-24" @default.
- W659353547 creator A5083275147 @default.
- W659353547 date "2012-01-01" @default.
- W659353547 modified "2023-09-27" @default.
- W659353547 title "Genetic Characterization of Chicken Models for Autoimmune Disease" @default.
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- W659353547 hasPublicationYear "2012" @default.
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