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- W65987029 abstract "Publisher Summary This chapter provides an overview of the regulation of β-adrenergic receptors by β-adrenergic agonistsrecent investigations in the laboratory that have concentrated on the endeavors to define the molecular mechanisms necessary for the phenomenon of catecholamine-induced tolerance or desensitization. It also discusses the molecular mechanisms necessary for the phenomenon of catecholamine-induced tolerance or desensitization. By desensitization, it is meant loss of responsiveness of a tissue to the physiological effects of some specific drug or hormone effector. The important feature of such a desensitization phenomenon is the specificity for a particular type of drug. Specific desensitization phenomena emerge to be quite general, though not universal phenomena. The chapter also describes the method applied for direct study of β-adrenergic receptors. For the studies of desensitization, a series of in vivo experiments were started and it frogs were used and they were injected with β-adrenergic catecholamines. After varying periods of time or injection schedules, animals were sacrificed, and the status of the s-adrenergic receptor-adenylyl cyclase system in the frog erythrocyte was studied." @default.
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- W65987029 date "1978-01-01" @default.
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- W65987029 title "Regulation of β-Adrenergic Receptors by β-Adrenergic Agonists" @default.
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- W65987029 doi "https://doi.org/10.1016/b978-0-12-526303-0.50012-6" @default.
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