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- W66056152 abstract "Abstract Vaccine-based immune therapy has shown minimal efficacy against established tumors. However, vaccination in the adjuvant setting prolongs disease-free survival. We previously demonstrated that CXCR3 expression by tumor antigen-specific T cells correlates with this. We hypothesized that melanoma engraftment may induce spatially- and temporally-restricted expression of CXCR3 chemokines in the tumor microenvironment, leading to transient infiltration of CXCR3+ T cells into tumor. We used a model of murine metastatic-like melanoma to evaluate tyrosinase expression as a measure of tumor burden. We observed a positive correlation between tyrosinase and CXCL9 (r2 = 0.73) and CXCL10 (r2 = 0.86) expression over time, demonstrating that melanoma growth in the lung is sufficient to induce CXCR3-cognate chemokines. In a time-course study, we observed that CXCL9 and CXCL10 expression decrease after day 15; we hypothesize that diminished chemokine production is due to reduced interferon signaling. We are investigating this possibility. Our preliminary flow cytometry analyses suggest a positive correlation between CD8+ T cell infiltration and the expression of CXCL9/10, suggesting that metastatic melanomas are transiently receptive to T cell infiltration. Therefore, successful immunotherapy of metastatic melanoma may require adjuvant therapy to induce or extend the chemotactic window for T cell infiltration." @default.
- W66056152 created "2016-06-24" @default.
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- W66056152 date "2013-05-01" @default.
- W66056152 modified "2023-09-26" @default.
- W66056152 title "Regulation of CXCR3 chemokine production and CD8+ T cell infiltration in the metastatic melanoma microenvironment (P5091)" @default.
- W66056152 doi "https://doi.org/10.4049/jimmunol.190.supp.129.10" @default.
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